Skip to main content

Table 2 Proteins involved in redox balance

From: The impact of surfactant protein-A on ozone-induced changes in the mouse bronchoalveolar lavage proteome

  

Normalized Volumes

Mean (SD)

WTFA vs WTO3

p ≤ 0.05

Normalized Volumes

Mean (SD)

KOFA vs KOO3

p ≤ 0.05

WTFA vs KOFA

p ≤ 0.05

WTO3 vs KOO3

p ≤ 0.05

  

WTFA

WTO3

 

KOFA

KOO3

   

Aldehyde dehydrogenase AHD-M1

↓

1.24

(0.163)

0.93

(0.286)

 

1.23

(0.163)

0.86

(0.140)

*

  

Aldehyde dehydrogenase

(EC 1.2.1.5)

↓

2.75

(0.471)

1.83

(0.570)

*

2.57

(0.365)

1.68

(0.362)

*

  

Aldose reductase

(EC 1.1.1.21)

↓

1.84

(0.193)

1.60

(0.294)

 

1.88

(0.362)

1.53

(0.348)

   

Apolipoprotein A-I

↑

1.59

(0.300)

2.18

(0.350)

*

2.24

(0.668)

4.41

(1.038)

*

 

*

Apolipooprolein A-IV

↑

2.50

(0.221)

3.01

(0.306)

*

2.69

(0.122)

3.27

(0.611)

   

Carbonyl reductase 2

↓

4.47

(0.537)

2.66

(1.329)

*

4.67

(0.543)

2.36

(0.453)

*

  

Ceruloplasmin isoform

↑

7.51

(0.766)

9.48

(1.487)

.056

7.53

(0.960)

9.39

(1.337)

.065

  

Cytosolic malate dehydrogenase

↓

1.18

(0.126)

0.80

(0.234)

*

1.09

(0.141)

0.80

(0.124)

*

  

Ferritin light chain

↓

1.43

(0.325)

1.21

(0.180)

 

1.34

(0.382)

1.13

(0.380)

   

Gelsolin

↑

7.07

(1.072)

11.69

(3.636)

.051

6.87

(0.347)

11.89

(1.682)

*

  

Glutathione S-transferase A4 (GST A4-4)

↓

1.41

(0.153)

0.80

(0.445)

*

1.32

(0.148)

0.65

(0.146)

*

  

Glutathione S-transferase omega 1

↓

3.52

(0.140)

2.78

(0.416)

*

2.94

(0.422)

2.77

(0.986)

 

*

 

Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)

↓

2.54

(0.750)

1.94

(1.125)

 

1.99

(0.379)

1.48

(0.241)

.067

  

Heat shock protein 70

↑

3.93

(0.807)

5.82

(1.173)

*

4.64

(0.556)

7.79

(1.026)

*

 

*

Hemopexin

↑

9.19

(1.184)

10.85

(1.000)

.076

11.49

(0.759)

13.71

(0.905)

*

*

*

Isocitrate dehydrogenase cytoplasmic (EC 1.1.1.42)

↑

2.14

(0.119)

2.12

(0.152)

 

1.64

(0.241)

1.97

(0.662)

 

*

 

Lactate dehydrogenase 2,

B chain

↓

1.26

(0.417)

1.03

(0.520)

*

1.05

(0.179)

0.84

(0.062)

.072

  

Peroxiredoxin 6 (Antioxidant protein 2; AOP2)

↓

5.60

(0.884)

3.35

(1.694)

.057

5.39

(0.486)

3.11

(0.667)

*

  

Protein disulfide-isomerase A3 (EC 5.3.4.1)

↓

5.62

(1.658)

4.87

(1.685)

 

4.67

(0.956)

4.64

(0.211)

   

Retinal dehydrogenase (RALDH1)(EC 1.2.1.36)

↓

7.88

(1.629)

5.55

(1.817)

 

7.85

(1.118)

5.07

(1.220)

*

  

Selenium binding protein 1

↓

1.42

(0.177)

0.83

(0.402)

*

1.39

(0.212)

0.68

(0.105)

*

  

Selenium binding protein 2

↓

5.61

(0.794)

3.53

(1.407)

*

5.33

(0.742)

3.00

(0.472)

*

  
  1. The proteins assigned to the redox balance category (RED) are listed (n = 22). An arrow indicates whether levels of expression are increased (↑) or decreased (↓) in response to ozone. The mean values for the normalized volumes and standard deviations for each named protein are given for WTFA, WTO3, KOFA, and KOO3. The asterisk indicates whether the p-value for the comparisons of WTFA vs. WTO3; KOFA vs. KOO3; WTFA vs. KOFA; and WTO3 vs. KOO3 was ≤ 0.05. Values that were slightly above 0.05 are also given.