Proteins differently expressed at the age of 52 and 76 weeks versus 28 weeks. (A) male, (B) female. The vertical axis corresponds to differential spot intensity, above the 0 value for the up-regulated protein-spots and below the 0 value for the down-regulated ones. According to 28 weeks old group, in the horizontal axis the down-regulated proteins are organised with the lowest values on the left side and the up-regulated ones show the highest values on the right side. Statistically significant folds (one-way ANOVA, p < 0.05) are indicated with asterixes.