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Table 4 Glucose-regulated INS-1E proteins

From: Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion

Protein mass (kDa)

pI

Protein expression ratio G20/G5.5

5.74

 

0.63

5.81

 

0.70

7.22

 

0.79

11.87

 

1.21

40.19

 

1.36

26 Rab2

5.9

1.7

28

7.6

3.51

35

7.9

34.8

38

6.0

1.25

39

8.7

1.29

40 Hnrnpa3, Hnrpa3

8.6

1.24

41

5.1

2.07

41

5.9

1.16

43 Pgk1, Pgk-1

8.2

1.57

45 Psma6

7.5

1.43

50

4.5

55.9

51 Ndufv1

7.9

1.18

55

6.0

1.26

57

6.3

2.52

58 G6pdx, G6pd

5.9

1.69

59 RGD1561681_predict.

7.8

1.75

61 Tcp1, Cct1, Ccta

5.8

1.53

61

5.8

1.79

63

5.0

1.51

63

5.8

1.16

65

6.0

1.31

69

5.9

1.27

71

6.0

1.80

72 Gars

5.8

2.15

73

5.7

1.42

81

5.5

1.27

89 Ganab

5.6

1.46

90 Ganab

5.6

1.37

93 Lonp1, Lon, Prss15

5.8

1.86

  1. INS-1E cells were cultured at 5.5 or 20 mM glucose for 48 hours. After culture, cells were lysed and protein profiles generated by SELDI-TOF-MS using Q10-array or by 2D-PAGE. Masses of differentially expressed proteins obtained by SELDI-TOF-MS (5 first proteins) or by 2D-PAGE are listed. Gene names of identified proteins are indicated. Results are means ± SEM 4–6 independent experiments.
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