Skip to main content

Table 1 Significant spots categorized by expression pattern

From: Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes

Trend x i y i z i n (spots) n (significant) Examples
Up-regulated in oncogene-expressing cells >0 >0 <0 325 57 Oncoprotein DJ-1, ezrin, multiple HSPs, metabolic, and regulatory proteins
  >0 >0 >0 31 5 HSPB1 (2 forms), peroxiredoxin-3
Mixed regulation in oncogene-expressing cells >0 <0 <0 21 4 HSPA1
  >0 <0 >0 38 0 (none)
  <0 >0 >0 49 3 p16ink4a, keratin 7 (2 forms)
  <0 >0 <0 69 3 Galectin-7
Down-regulated in oncogene-expressing cells <0 <0 <0 10 1 (none)
  <0 <0 >0 198 97 Serpin B5, annexin A2, 14-3-3σ, lamin A/C multiple cytokeratins
Total 741 170  
  1. All 741 protein spots were classified according to the algebraic sign of x i , y i , and z i . For each of eight possible permutations, the table provides the total number of spots and the number of spots evaluated as potentially significant using statistical and biological criteria specified in Additional file 1. The table also provides examples of identified proteins in each category.