Figure 2From: Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix Cell migration of the WA17 cell line model of DS. (A) A9 and WA17 cells were grown until confluent, and treated with 10 mg/ml mitomycin C for 2 h, before a scratch wound was introduced using a yellow pipette tip. Cells were then incubated for 3 days in normal growth media. Pictures were taken at 0, 1, 2 and 3 days after wounding. (B) Pictures from 4 non-overlapping scratch wounds of each of 3 independent cultures (n = 12 data points for each cell line) from part A were taken and cells migrated into the wound site were quantified (Open bars A9, filled bars WA17). Data are presented as mean ± SD (**p < 0.001 t-test comparing A9 versus WA17).Back to article page