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Table 8 MS/MS identification results

From: Prediction of outcome of non-small cell lung cancer patients treated with chemotherapy and bortezomib by time-course MALDI-TOF-MS serum peptide profiling

Peptide ID

m/z

Peptide residue location

Peptide amino acid sequence

Signature(s)

BK

904.4676

381-388

RPPGFSPF

Time course (44)

P-FPA

1616,6366

20-35

ADS*GEGDFLAEGGGVR

Time course (44); PFS (13);

Response (10);

NSCLC vs. Healthy (47)

FPA

1536,6906

20-35

ADSGEGDFLAEGGGVR

Time course (44)

FPA

1350,6275

22-35

SGEGDFLAEGGGVR

Time course (44)

FPA

1263,5958

23-35

GEGDFLAEGGGVR

Time course (44)

Glu-FPB

1552.669

31-44

EGVNDNEEGFFSA

Time course (44)

FPB

1129.4849

34-43

NDNEEGFFSAR

Time course (44)

C3f

1865,0022

1304-1319

SSKITHRIHWESASLL

Time course (44)

C3f

1777,966

1305-1319

SKITHRIHWESASLL

Time course (44)

C3f

1690,9254

1306-1319

KITHRIHWESASLL

Time course (44)

C3 beta

2324,1475

23-42

SPMYSIITPNILRLESEETM

NSCLC vs. Healthy (47)

C3 beta

2193,1036

23-41

SPMYSIITPNILRLESEET

NSCLC vs. Healthy (47)

Hbα

3473,7545

2-34

VLSPADKTNVKAAWGKVGAHAGEYGAEALERMF

NSCLC vs. Healthy (47)

Hbα

3326,6863

2-33

VLSPADKTNVKAAWGKVGAHAGEYGAEALERM

NSCLC vs. Healthy (47)

seAlb

2567,3659

27-48

HKSEVAHRFKDLGEENFKALVL

Time course (44)

ITIH4

3156,6207

617-644

NVHSGSTFFKYYLQGAKIPKPEASFSPR

Time course (44);

NSCLC vs. Healthy (47)

CFXIII A

2602,3048

43-67

AVPPNNSNAAEDDLPTVELQGVVPR

Time course (44)

  1. Peptides were identified from the 44-peptide ion time course signature ("time course (44)"), the 13-peptide ion "long PFS" vs. "short PFS" signature ("PFS (13)"), the 10-peptide ion "PR" vs. "no PR" signature ("Response (10)") and the 47-peptide ion NSCLC vs. Healthy comparison ("NSCLC vs. Healthy (47)"). Abbreviations: FPA: fibrinopeptide A; P-FPA: phospho-fibrinopeptide A (phosphorylation site indicated by *); FBP: fibrinopeptide B; Glu-FBP: Glu-1-Fibrinopeptide B; C3f: complement C3f; C3b: complement C3beta; Hb alpha: hemoglobin alpha; seAlb: serum albumen; ITIH4: inter-alpha-trypsin inhibitor heavy chain H4; CFXIIIA: coagulation factor XIIIA.