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Table 1 Differentially expressed plasma proteins

From: Plasma and urine biomarkers in acute viral hepatitis E

Identifier

Protein Name

Accession Number

Glyco/Non-Glyco

Fold-change

Acute phase reactant

P1

Lipocalin

Plasma retinol binding protein

AAF69622

1RBP

NG/G

-1.47(NG)

+1.32(NG)

-7.68(G)

-6.09(G)

No

?(-)

P2

Transthyretin (prealbumin)

AAA61181

NG

 

Yes(-)

NG-3

- Transthyretin precursor

- Interleukin 6 signal transducer isoform 1 precursor

- Sequence 17 from patient EP1229047 unnamed protein product

- HS422F24 chromosome 6 orf1

AAA61181

CAD48779

CAD48776

CA120537

NG

 

Yes(-)

NG-4

- Transthyretin (prealbumin)

- Annexin A2 (Annexin II) (Lipocortin II) (Calpactin I Heavy Chain)

- Possible J56 gene segment (fragment)

VBHU

ANXA2_HUMAN

NG

 

Yes(-)

P3

Fibrinogen chain

FGHUB

G

+1.14

-1.59

Yes(+)

P4

- Alpha-2-HS glycoprotein

- Cystatin C

WOHU

AAF69649

G

+1.45

+1.02

Yes(-)

No

P5

HP-Protein Haptoglobin

Q6NSB4 AAC27432

G

-2.27

-2.85

Yes (+)

P6

Beta-2 glycoprotein 1

1QUBA

G

-1.36

-2.58

No

P8

Alpha1 acid glycoprotein precursor 2

Alpha1 acid glycoprotein precursor 1

OMHU2

OMHU1

Q61B74

G

-2.15

-2.33

Yes (+)

P9

Fibrinogen

FGHUB

G

-0.82

-2.24

Yes (+)

P10

Hemopexin

CAA26382

G

-2.71

-2.78

Yes (+)

P11

Apolipoprotein A1

CAA00975

NG/G

-3.03(G)

-7.90(G)

-1.47(NG)

-1.38(NG)

No

NG-1

Apolipoprotein A1

CAA00975

NG/G

  

P12

Fibrinogen γ-A chain precursor

Fibrinogen γ-B chain precursor

FGHUG

FGHUGB

NG/G

+2.20(NG)

+1.51(NG)

 

P13

Tau Tubulin Kinase

Hypothetical protein DKFZp686J1375

Q8IWY7

Q7Z3Q0

NG

+1.49

+1.43

No

P14

  

NG

+2.43

+2.94

 

P15

Serum Amyloid P Precursor

YLHUP

G

-2.52

Yes (+)

NG-2

Vitamin D Binding Protein

    
  1. The differentially expressed plasma proteins from Figure 2 were analysed by DeCyder 2D v6.5 and identified by mass spectrometry. The table shows the spot intensity fold-changes in hepatitis E patients compared to healthy controls in two independent plasma pool experiments. The "+" and "-" values indicate increased or decreased expression, respectively, in patients compared to controls.