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Table 1 Auxiological data for the study groups

From: Proteins related to lipoprotein profile were identified using a pharmaco-proteomic approach as markers for growth response to growth hormone (GH) treatment in short prepubertal children

A) Total group (n = 128; 38 girls, 90 boys) B) ISS (n = 89, 25 girls, 64 boys) C) GHD (n = 39, 13 girls, 26 boys)
Variables Median Min Max Median Min Max Median Min Max
At birth
   Gestational age (weeks) 39 33 42 39 33 42 39 36 42
   Height SDS -0,66 -2,52 1,68 -0,74 -2,52 1,68 -0,70 -2,52 1,68
At GH start
   Age (yrs) 7,27 3,05 10,95 7,32 3,24 10,95 7,14 3,05 10,94
   Height SDS -2,64 -4,10 -1,77 -2,64 -4,10 -1,77 -2,59 -3,65 -1,98
   Weight SDS -2,24 -4,31 0,26 -2,39 -4,31 -0,45 -2,03 -3,80 0,26
   BMI SDS -0,47 -3,35 2,11 -0,55 -3,35 1,88 -0,20 -1,80 2,11
   GHmax AITT (mU/L) 16,95 1,10 62,90 19,60 1,10 62,90 15,10 1,60 22,30
   GHmax 24 h (mU/L) 24,85 0,80 58,10 28,10 12,70 58,10 14,70 0,80 22,10
   Diff MPHSDS -1,73 -3,53 -0,61 -1,72 -3,53 -0,61 -1,77 -2,45 -0,78
   HDL (mg/L) 1,44 0,64 2,70 1,44 0,64 2,70 1,44 0,91 2,24
   IGF-I SDS -1,10 -5,17 2,25 -1,19 -3,84 2,25 -1,06 -5,17 0,91
   GH dose (μg/kg/day) 44,20 17,00 102,00 44,20 17,00 102,00 44,20 17,00 68,00
After 2 yrs of treatment
   Height SDS -1,45 -3,00 0,20 -1,45 -3,00 0,20 -1,45 -2,42 0,05
   Delta height SDS 2 yrs 1,26 0,23 2,69 1,22 0,23 2,69 1,31 0,51 2,39
   BMI SDS -0,24 -3,10 2,03 -0,05 -3,10 1,88 -0,08 -2,14 2,03
   HDL (mg/L) 1,36 0,76 2,06 1,37 0,76 2,06 1,28 0,94 1,97
   IGF-I SDS 1,57 -1,48 4,21 1,49 -0,65 3,82 1,57 -1,48 4,21
  1. AITT, arginine--insulin tolerance test; GHmax, maximum peak of GH secretion; IGF-I, insulin-like growth factor I; GHD, GH deficient; MPH, mid-parental height; diffMPHSDS, difference in height SDS of the child versus its mid-parental height SDS
  2. 0.1 U GH/kg/day = 33 μg/kg/day
  3. The reference values used for SDS calculations were obtained from [18] for height and weight and [15] for IGF-I.