A) Total group (n = 128; 38 girls, 90 boys)
|
B) ISS (n = 89, 25 girls, 64 boys)
|
C) GHD (n = 39, 13 girls, 26 boys)
|
---|
Variables
|
Median
|
Min
|
Max
|
Median
|
Min
|
Max
|
Median
|
Min
|
Max
|
At birth
|
Gestational age (weeks)
|
39
|
33
|
42
|
39
|
33
|
42
|
39
|
36
|
42
|
Height SDS
|
-0,66
|
-2,52
|
1,68
|
-0,74
|
-2,52
|
1,68
|
-0,70
|
-2,52
|
1,68
|
At GH start
|
Age (yrs)
|
7,27
|
3,05
|
10,95
|
7,32
|
3,24
|
10,95
|
7,14
|
3,05
|
10,94
|
Height SDS
|
-2,64
|
-4,10
|
-1,77
|
-2,64
|
-4,10
|
-1,77
|
-2,59
|
-3,65
|
-1,98
|
Weight SDS
|
-2,24
|
-4,31
|
0,26
|
-2,39
|
-4,31
|
-0,45
|
-2,03
|
-3,80
|
0,26
|
BMI SDS
|
-0,47
|
-3,35
|
2,11
|
-0,55
|
-3,35
|
1,88
|
-0,20
|
-1,80
|
2,11
|
GHmax AITT (mU/L)
|
16,95
|
1,10
|
62,90
|
19,60
|
1,10
|
62,90
|
15,10
|
1,60
|
22,30
|
GHmax 24 h (mU/L)
|
24,85
|
0,80
|
58,10
|
28,10
|
12,70
|
58,10
|
14,70
|
0,80
|
22,10
|
Diff MPHSDS
|
-1,73
|
-3,53
|
-0,61
|
-1,72
|
-3,53
|
-0,61
|
-1,77
|
-2,45
|
-0,78
|
HDL (mg/L)
|
1,44
|
0,64
|
2,70
|
1,44
|
0,64
|
2,70
|
1,44
|
0,91
|
2,24
|
IGF-I SDS
|
-1,10
|
-5,17
|
2,25
|
-1,19
|
-3,84
|
2,25
|
-1,06
|
-5,17
|
0,91
|
GH dose (μg/kg/day)
|
44,20
|
17,00
|
102,00
|
44,20
|
17,00
|
102,00
|
44,20
|
17,00
|
68,00
|
After 2 yrs of treatment
|
Height SDS
|
-1,45
|
-3,00
|
0,20
|
-1,45
|
-3,00
|
0,20
|
-1,45
|
-2,42
|
0,05
|
Delta height SDS 2 yrs
|
1,26
|
0,23
|
2,69
|
1,22
|
0,23
|
2,69
|
1,31
|
0,51
|
2,39
|
BMI SDS
|
-0,24
|
-3,10
|
2,03
|
-0,05
|
-3,10
|
1,88
|
-0,08
|
-2,14
|
2,03
|
HDL (mg/L)
|
1,36
|
0,76
|
2,06
|
1,37
|
0,76
|
2,06
|
1,28
|
0,94
|
1,97
|
IGF-I SDS
|
1,57
|
-1,48
|
4,21
|
1,49
|
-0,65
|
3,82
|
1,57
|
-1,48
|
4,21
|
- AITT, arginine--insulin tolerance test; GHmax, maximum peak of GH secretion; IGF-I, insulin-like growth factor I; GHD, GH deficient; MPH, mid-parental height; diffMPHSDS, difference in height SDS of the child versus its mid-parental height SDS
- 0.1 U GH/kg/day = 33 μg/kg/day
- The reference values used for SDS calculations were obtained from [18] for height and weight and [15] for IGF-I.