Figure 3From: Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice Network analysis of BAL proteome changes under baseline conditions. Changes in levels of expression between WT and SP-A-/- mice under baseline conditions and at 4 hr after infection (Figure 4) were analyzed using the Ingenuity Pathway program focusing on pathways related to lung disease (shown as Function (Fx) in olive green squares). Proteins undergoing significant changes are indicated in bold. Changing proteins that were not included in the pathway are shown in the inset in the lower right corner. The relationship between symbol color and relative levels of expression is shown in the upper left corner. Unshaded proteins in the pathway were not identified in our gels. The proteins included in the analysis and the Ingenuity abbreviation are listed below (see also Table 1): Cytosolic malate dehydrogenase: MDH1; Ferritin light chain 1: FTL; Gamma-actin: ACTG1; Gelsolin: GSN; Glutathione S-transferase, alpha 3: GSTA3; Glutathione S-transferase, alpha 4: GSTA4; Glutathione S-transferase, mu 1: GSTM5; Glutathione S-transferase, omega 1: GSTO1; Glutathione S-transferase, Ya chain (GST class-alpha): GSTA5; Haptoglobin: HP; Hemoglobin subunit alpha: HBA2; Isocitrate dehydrogenase: IDH1; Keratin complex 1, acidic, gene 10: KRT10; Kpnb1 protein b: KPNB1; Lactate dehydrogenase 2, B chain: LDHB; Lysozyme 2:; LYZ; Murinoglobulin-1 precursor: MUG1; Myosin heavy chain IIB: MYH4; Peroxiredoxin 1: PRDX1; Peroxiredoxin 6: PRDX6; Pregnancy zone protein: PZP; Prothrombin precursor: F2; Pulmonary surfactant associated protein A precursor: SFTPA1; Rho GDP dissociation inhibitor (GDI) alpha: ARHGDIA; SEC14-like 3: SEC14L3; Selenium binding protein 1: SELENBP1; Toll-like receptor 13 precursor: TLR13; Transferrin: TF; Tyrosine-3-monooxygenase/tryptophan 5-monooxygenase activation protein, Epsilon polypeptide: YWHAEBack to article page