Figure 5

Sequences of 2 protease inhibitor proteins. These protein sequences are deduced from translated sequences of the entry P0012N13_463 (A) and ML3E9 (B). (A) An alignment of the 2 Kunitz domains with other protease inhibitor proteins from diverse mollusc and metazoan origins indicates that the Kunitz-like protein family is highly conserved. (B) An alignment of the 3 WAP domains of Has-Perlwapin with other molluscan and metazoan Perlwapin proteins reveals the high degree of conservation of the cysteine residues. Positions shaded in black indicate cases where more than 70% of the residues are identical, and grey where at least 40% of the residues are identical or share biochemical similarity with the consensus residue. GenBank or Swiss-Prot numbers are indicated on the left.