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Table 2 Dose-dependent downregulated protein spots in response to Pb (II)

From: Characterization of proteome alterations in Phanerochaete chrysosporium in response to lead exposure

   

Treatment/Control Ratio

  

KOG Class

Protein ID

Putative Function

25 uM

50 uM

100 uM

Subcellular location *

Multiple spots

Amino acid transport and metabolism

138721a

Glutamate/leucine/phenylalanine/valine dehydrogenases

0,50

0,22

1,32

C

2

 

139320b

Isocitrate dehydrogenase, alpha subunit

0,12

0,02

0,01

Mit

3

 

139663&138887a

Methionine synthase II (cobalamin-independent)-//-aconitate hydratase

0,24

0,09

0,08

C

4

 

139663&138887b

Methionine synthase II (cobalamin-independent)-//-aconitate hydratase

0,30

0,06

0,15

C

4

 

139663&138887c

Methionine synthase II (cobalamin-independent)-//-aconitate hydratase

0,14

0,00

0,05

C

4

 

139663&138887d

Methionine synthase II (cobalamin-independent)-//-aconitate hydratase

0,26

0,18

0,06

C

4

 

139663d

Methionine synthase II (cobalamin-independent)

0,15

0,17

0,66

C

6

 

139663e

Methionine synthase II (cobalamin-independent)

0,20

0,20

0,60

C

6

 

139663f

Methionine synthase II (cobalamin-independent)

0,07

0,02

0,01

C

6

Cytoskeleton

139298c

Actin and related proteins

0,59

0,16

1,15

Cysk

4

Energy production and conversion

1056

Zinc-binding oxidoreductase

0,14

0,09

0,25

C

-

 

123932

Fumarate reductase, flavoprotein subunit

0,14

0,07

0,34

C

-

Lipid transport and metabolism

10015

Acetyl-CoA acetyltransferase

0,66

0,24

0,88

C

2

NA

8290

hypothetical protein

0,40

0,22

0,28

C

-

 

140431b

hypothetical protein

0,04

0,03

0,01

C

4

 

140431c

hypothetical protein

0,19

0,03

0,07

C

4

 

140431d

hypothetical protein

0,52

0,22

0,11

C

4

Posttranslational modification,

122440

Molecular chaperones HSP70/HSC70, HSP70 superfamily

0,53

0,09

0,84

C

6

protein turnover, chaperones

131983b

Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily

0,71

0,11

0,19

Ext

2

Secondary metabolites biosynthesis, transport and catabolism

8565

Hydroxysteroid 17-beta dehydrogenase 11

0,45

0,29

1,24

Mit

-

Signal transduction mechanisms

10895

Glycosylphosphatidylinositol-specific phospholipase C

0,11

0,30

1,19

Cyto_ nucl

-

  1. *C; cytoplasmic, Ext; extracellular, Mit; mitochondrial, Nuc; Nuclear, Cysk; cytoskeleton, Cyto_nucl; cytoplasmic_nuclear
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Proteome Science

ISSN: 1477-5956