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Figure 4 | Proteome Science

Figure 4

From: Systems analysis of endothelial cell plasma membrane proteome of rat lung microvasculature

Figure 4

Global protein-protein interaction network of the EC PM membranome. All proteins in the EC PM membranome were imported into IPA (see Materials and Methods). Molecules found within the IPA knowledge database (IPAKDB) were applied to the network analysis and only direct relationships among the molecules were allowed. The top 14 networks were merged to create this global map. Known PM- or EC-associated functions are highlighted with blue for EC-associated functions; yellow for neuron-associated functions; green for PM-associated functions; pink for adhesion-associated functions; purple for signaling pathways; light pink for mechanotransduction/mechanosignaling; orange for cell movement and morphology; and white for transport and trafficking. Red nodes indicate enriched proteins in the PM (P/H > 1.0). Green nodes indicate the depletion of the protein in P (P/H < 1.0). The darker the red/green is, the greater the enrichment or depletion. White nodes indicate the proteins were not found in the membranome.

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