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Table 3 Top-ranked protein-protein interaction networks in IPA.

From: Systems analysis of endothelial cell plasma membrane proteome of rat lung microvasculature

ID

Top Functions

Score

Focus Molecules

1

Cell Morphology, Cellular Development, Cellular Function and Maintenance

46

33

2

Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry

39

30

3

Cellular Assembly and Organization, Cancer, Reproductive System Disease

39

30

4

Cancer, Reproductive System Disease, Cardiovascular System Development and Function

37

29

5

Gene Expression, Cell Cycle, Cancer

35

28

6

Cell-To-Cell Signaling and Interaction, Immune Response, Cellular Development

33

27

7

Inflammatory Disease, Respiratory Disease, Protein Synthesis

33

27

8

Cell Signaling, Vitamin and Mineral Metabolism, Cancer

27

24

9

Cellular Assembly and Organization, Cellular Compromise, Cell Morphology

27

24

10

Cell Signaling, Connective Tissue Disorders, Dermatological Diseases and Conditions

25

23

11

Lipid Metabolism, Nucleic Acid Metabolism, Small Molecule Biochemistry

20

20

12

Cell-To-Cell Signaling and Interaction, Tissue Development, Cancer

19

19

13

Cellular Development, Cell Morphology, Respiratory Disease

17

18

14

Cancer, Cellular Movement, Cell Morphology

16

17

15

Neurological Disease, Cell Cycle, Genetic Disorder

16

17

16

Cancer, Cellular Movement, Cell Morphology

16

17

17

Amino Acid Metabolism, Post-Translational Modification, Small Molecule Biochemistry

16

17

18

Genetic Disorder, Neurological Disease, Protein Synthesis

16

17

19

Cancer, Cell Morphology, Hematological Disease

15

14

20

Post-Translational Modification, Protein Folding, Molecular Transport

14

16

21

Cell Death, Neurological Disease, Cancer

14

16

22

Cellular Function and Maintenance, Small Molecule Biochemistry, Cell Cycle

14

16

23

Cell Signaling, Cell Morphology, Cellular Function and Maintenance

14

16

24

Gene Expression, Cell-To-Cell Signaling and Interaction, Renal and Urological System Development and Function

13

14

25

DNA Replication, Recombination, and Repair, Nucleic Acid Metabolism, Small Molecule Biochemistry

13

15

26

Cellular Assembly and Organization, Cell Signaling, Cellular Function and Maintenance

13

15

27

Free Radical Scavenging, Cell-To-Cell Signaling and Interaction, Cell Morphology

13

15

28

Cellular Function and Maintenance, Cell Signaling, Molecular Transport

13

15

29

Gene Expression, RNA Post-Transcriptional Modification, Cancer

13

15

30

Cell Cycle, Tissue Development, Gene Expression

12

14

31

Cellular Development, Nervous System Development and Function, Tissue Morphology

12

14

32

Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry

10

13

  1. This table lists all networks having a score ≥10 from the IPA algorithms (see Materials and Methods). From the left to right, ranks from IPA, functions in that rank, score, and the number of molecules from our dataset in that group.