Table 4 Proteins involved in neuron-restricted processes found in the EC PM membranome.
From: Systems analysis of endothelial cell plasma membrane proteome of rat lung microvasculature
JSID | Accession Number | Description | Quantity (ng/mg membrane) | P/H | Location | Tissue specificity (UniProt & GO) |
|---|---|---|---|---|---|---|
JS40001915 | Q9Z270 | Vesicle-associated membrane protein-associated protein A [19] | 645.54 | 0.523 | Plasma membrane; vesicle | Ubiquitous |
JS40008100 | NP_001100068 | catenin (cadherin associated protein), alpha 2 (N-catenin) [24] | 461.25 | 3.92 | plasma membrane, Cytoskeleton, cell junctioin | Brain |
JS40003261 | Q9JK11 | Reticulon-4 (nogo) [18] | 343.33 | 1.09 | Endoplasmic reticulum | isoform 1 is expressed mainly in the nervous system, Isoforms 2 and 3 are detected in other tissues other than CNS |
JS40015951 | Q9Z269 | Vesicle-associated membrane protein-associated protein B [19] | 267.42 | 0.461 | Plasma membrane; vesicle | Ubiquitous |
JS40003589 | Q9QWJ9 | Neuropilin-1, CD304 [29] | 218.03 | 2.342 | Plasma membrane | Neuron and EC |
JS40013915 | Q9JLU4 | Shank3 [Proline-rich synapse associated protein 2] [21] | 172.77 | 4.844 | Plasma membrane; cytoplasm, synapse | Widely expressed in brain |
JS40001396 | Q64548 | Reticulon-1 [30] | 85.81 | 3.637 | Endoplasmic reticulum | Expressed predominantly in central and peripheral nervous system. isoform RTN1-B is restricted to particular neuronal types |
JS40046849 | Q6GMN2 | Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1A2) [27] | 25.66 | ∞ | Plasma membrane; cytoplasm, cell projection | Ubiquitous |
JS40014656 | O08816 | Neural Wiskott-Aldrich syndrome protein (N-Wash) [22] | 16.95 | ∞ | Cytoskeleton; nucleus | NA |
JS40028986 | NP_001101576 | Plexin-B2 [28] | 14.73 | 0.553 | Plasma membrane | NA |
JS40004987 | Q63198 | Contactin-1 [Neural cell surface protein F3 [23] | 7.97 | ∞ | Plasma membrane | NA |
JS40001709 | Q6RJR6 | Reticulon 3 protein [26] | 2 | 416.78 | golgi; ER | many tissues |
JS40039470 | Q8NFP9 | Neurobeachin [20] | 1.85 | ∞ | Peripheral membrane, cytoplasm | Predominant in many brain structures. Also in many other tissues |
JS40011947 | P21263 | Nestin [25] | 1.17 | ∞ | unknown | CNS stem cell |