Figure 1

Changes in HDL composition upon LPS challenge. A. Virtual gel-views representing the HDL composition after SELDI-TOF MS analysis. Depicted are profiles from on-chip captured HDL from baseline (BL) to 24 hours after endotoxin challenge. All spectra were normalized on total ion current and baseline corrected and subsequently translated to the "virtual gel-view" output format. The arrows indicate those markers which demonstrated a significant dynamic change over time (adjusted p < 0.05) after LPS challenge. B. SAA response in healthy individuals after LPS challenge. SAA levels, of the low (white bars) and high (black bars) HDL cholesterol groups, as determined by ELISA, are depicted. The data represent mean ± SD. * indicates statistical significant difference between the low and high cholesterol HDL group (p < 0.05). From t = 4 hours and all following timepoints a statistical significant difference compared to baseline condition was reached (p < 0.001).