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Table 2 List of upregulated proteins in periodontitis GCF.

From: Identification of azurocidin as a potential periodontitis biomarker by a proteomic analysis of gingival crevicular fluid

# Identified Proteins Accession Number Biological process Cellular component Molecular function Molecular Weight N MP MP/N fold N/MP fold
1 Catalase IPI00465436 hydrogen peroxide removal peroxisome mitogen oxidoreductase peroxidase 60 kDa 0.3 ± 0.4 3.0 ± 1.4 12.0 0.1
2 Adenylyl cyclase-associated protein 1 IPI00008274 signal transduction cell membrane actin binding 52 kDa 0.5 ± 0.7 5.8 ± 6.0 11.5 0.1
3 Plastin-2 IPI00010471 T cell activation cell junction calcium ion binding 70 kDa 2.0 ± 0.7 15.0 ± 12.7 7.5 0.1
4 Alpha-actinin-1 IPI00013508 negative regulation of cellular component cytosol actin binding 103 kDa 1.5 ± 0.7 10.3 ± 13.1 6.8 0.1
5 Fibrinogen beta chain IPI00298497 platelet activation external side of plasma membrane cell surface binding 56 kDa 0.8 ± 0.4 4.8 ± 1.8 6.3 0.2
6 Hornerin IPI00398625 keratinization   developmental protein 282 kDa 1.0 ± 1.4 5.5 ± 4.2 5.5 0.2
7 Isoform 1 of Myosin-9 IPI00019502 cell shape cytosol motor protein 227 kDa 4.8 ± 3.9 23.5 ± 26.2 4.9 0.2
8 Myeloblastin IPI00027409 collagen degradation   serine protease 28 kDa 2.3 ± 0.4 11.0 ± 2.8 4.9 0.2
9 Azurocidin IPI00022246 chemotaxis azurophil granule antimicrobial 27 kDa 2.0 ± 0.7 9.3 ± 1.8 4.6 0.2
10 Isoform 1 of Fibrinogen alpha chain IPI00021885 blood coagulation Secreted cell surface binding 95 kDa 0.8 ± 1.1 3.0 ± 2.1 4.0 0.3
11 Leukocyte elastase IPI00027769 inflammatory response secretory granule Serine protease 29 kDa 5.0 ± 4.2 16.0 ± 3.5 3.2 0.3
12 Matrix metalloproteinase-9 IPI00027509 collagen degradation extracellular matrix metalloprotease 78 kDa 3.8 ± 3.9 10.5 ± 12.7 2.8 0.4
13 HBD Hemoglobin subunit delta IPI00473011 oxygen transport hemoglobin complex oxygen binding 16 kDa 34.8 ± 7.4 94.8 ± 63.3 2.7 0.4
14 Coronin-1A IPI00010133 innate immune response cytoplasm actin filament binding 51 kDa 5.0 ± 2.8 13.0 ± 13.4 2.6 0.4
15 Rho GDP-dissociation inhibitor 2 IPI00003817 immune response cytoplasm GTPase activator 23 kDa 5.0 ± 3.5 12.0 ± 4.9 2.4 0.4
16 Keratin, type II cytoskeletal 5 IPI00009867 assembly intermediate filament structural constituent 62 kDa 9.8 ± 11.0 21.8 ± 13.1 2.2 0.4
17 Macrophage-capping protein IPI00027341 assembly cytoplasm nucleus actin binding 39 kDa 1.8 ± 2.5 3.8 ± 1.8 2.1 0.5
18 HBA2 Hemoglobin subunit alpha IPI00410714 oxygen transport hemoglobin complex oxygen binding 15 kDa 49.8 ± 20.9 105.5 ± 66.5 2.1 0.5
19 Keratin, type II cytoskeletal 1 IPI00220327 fibrinolysis intermediate filament structural constituent 66 kDa 93.0 ± 79.2 196.5 ± 193.0 2.1 0.5
20 Annexin A3 IPI00024095 defense response to bacterium phagocytic vesicle calcium-dependent phospholipid binding 36 kDa 4.5 ± 4.2 9.5 ± 0.7 2.1 0.5
21 Hemoglobin subunit beta IPI00654755 oxygen transport hemoglobin complex hypotensive agent 16 kDa 74.5 ± 7.1 155.8 ± 83.8 2.1 0.5
22 Keratin, type I cytoskeletal 9 IPI00019359 organization intermediate filament structural constituent 62 kDa 31.0 ± 22.6 64.8 ± 63.3 2.1 0.5
23 Keratin, type II cytoskeletal 2 epidermal IPI00021304 keratinization intermediate filament structural constituent 66 kDa 32.3 ± 39.2 65.0 ± 72.1 2.0 0.5
24 Actin-related protein 2 IPI00005159 cellular component cytoplasm actin binding 45 kDa 0.8 ± 1.1 1.5 ± 0.7 2.0 0.5
25 S100-A9 IPI00027462 chemotaxis extracellular region calcium ion-binding protein 13 kDa 44.8 ± 1.1 88.5 ± 1.4 2.0 0.5