Table 2 List of upregulated proteins in periodontitis GCF.

1

Catalase

IPI00465436

hydrogen peroxide removal

peroxisome

mitogen oxidoreductase peroxidase

60 kDa

0.3 ± 0.4

3.0 ± 1.4

12.0

0.1

2

Adenylyl cyclase-associated protein 1

IPI00008274

signal transduction

cell membrane

actin binding

52 kDa

0.5 ± 0.7

5.8 ± 6.0

11.5

0.1

3

Plastin-2

IPI00010471

T cell activation

cell junction

calcium ion binding

70 kDa

2.0 ± 0.7

15.0 ± 12.7

7.5

0.1

4

Alpha-actinin-1

IPI00013508

negative regulation of cellular component

cytosol

actin binding

103 kDa

1.5 ± 0.7

10.3 ± 13.1

6.8

0.1

5

Fibrinogen beta chain

IPI00298497

platelet activation

external side of plasma membrane

cell surface binding

56 kDa

0.8 ± 0.4

4.8 ± 1.8

6.3

0.2

6

Hornerin

IPI00398625

keratinization

developmental protein

282 kDa

1.0 ± 1.4

5.5 ± 4.2

5.5

0.2

7

Isoform 1 of Myosin-9

IPI00019502

cell shape

cytosol

motor protein

227 kDa

4.8 ± 3.9

23.5 ± 26.2

4.9

0.2

8

Myeloblastin

IPI00027409

collagen degradation

serine protease

28 kDa

2.3 ± 0.4

11.0 ± 2.8

4.9

0.2

9

Azurocidin

IPI00022246

chemotaxis

azurophil granule

antimicrobial

27 kDa

2.0 ± 0.7

9.3 ± 1.8

4.6

0.2

10

Isoform 1 of Fibrinogen alpha chain

IPI00021885

blood coagulation

Secreted

cell surface binding

95 kDa

0.8 ± 1.1

3.0 ± 2.1

4.0

0.3

11

Leukocyte elastase

IPI00027769

inflammatory response

secretory granule

Serine protease

29 kDa

5.0 ± 4.2

16.0 ± 3.5

3.2

0.3

12

Matrix metalloproteinase-9

IPI00027509

collagen degradation

extracellular matrix

metalloprotease

78 kDa

3.8 ± 3.9

10.5 ± 12.7

2.8

0.4

13

HBD Hemoglobin subunit delta

IPI00473011

oxygen transport

hemoglobin complex

oxygen binding

16 kDa

34.8 ± 7.4

94.8 ± 63.3

2.7

0.4

14

Coronin-1A

IPI00010133

innate immune response

cytoplasm

actin filament binding

51 kDa

5.0 ± 2.8

13.0 ± 13.4

2.6

0.4

15

Rho GDP-dissociation inhibitor 2

IPI00003817

immune response

cytoplasm

GTPase activator

23 kDa

5.0 ± 3.5

12.0 ± 4.9

2.4

0.4

16

Keratin, type II cytoskeletal 5

IPI00009867

assembly

intermediate filament

structural constituent

62 kDa

9.8 ± 11.0

21.8 ± 13.1

2.2

0.4

17

Macrophage-capping protein

IPI00027341

assembly

cytoplasm nucleus

actin binding

39 kDa

1.8 ± 2.5

3.8 ± 1.8

2.1

0.5

18

HBA2 Hemoglobin subunit alpha

IPI00410714

oxygen transport

hemoglobin complex

oxygen binding

15 kDa

49.8 ± 20.9

105.5 ± 66.5

2.1

0.5

19

Keratin, type II cytoskeletal 1

IPI00220327

fibrinolysis

intermediate filament

structural constituent

66 kDa

93.0 ± 79.2

196.5 ± 193.0

2.1

0.5

20

Annexin A3

IPI00024095

defense response to bacterium

phagocytic vesicle

calcium-dependent phospholipid binding

36 kDa

4.5 ± 4.2

9.5 ± 0.7

2.1

0.5

21

Hemoglobin subunit beta

IPI00654755

oxygen transport

hemoglobin complex

hypotensive agent

16 kDa

74.5 ± 7.1

155.8 ± 83.8

2.1

0.5

22

Keratin, type I cytoskeletal 9

IPI00019359

organization

intermediate filament

structural constituent

62 kDa

31.0 ± 22.6

64.8 ± 63.3

2.1

0.5

23

Keratin, type II cytoskeletal 2 epidermal

IPI00021304

keratinization

intermediate filament

structural constituent

66 kDa

32.3 ± 39.2

65.0 ± 72.1

2.0

0.5

24

Actin-related protein 2

IPI00005159

cellular component

cytoplasm

actin binding

45 kDa

0.8 ± 1.1

1.5 ± 0.7

2.0

0.5

25

S100-A9

IPI00027462

chemotaxis

extracellular region

calcium ion-binding protein

13 kDa

44.8 ± 1.1

88.5 ± 1.4

2.0

0.5