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Table 3 List of downregulated proteins in periodontitis GCF.

From: Identification of azurocidin as a potential periodontitis biomarker by a proteomic analysis of gingival crevicular fluid

# Identified Proteins Accession Number Biological process Cellular component Molecular function Molecular Weight N MP MP/N fold N/MP fold
1 Cystatin-A IPI00032325 keratinocyte cytoplasm cysteine-type endopeptidase inhibitor activity 11 kDa 4.5 ± 3.5 2.3 ± 1.1 0.5 2.0
2 Thymidine phosphorylase IPI00292858 chemotaxis   glycosyltransferase 50 kDa 7.5 ± 2.8 3.8 ± 0.4 0.5 2.0
3 Cystatin-B IPI00021828   cytoplasm nucleus protease inhibitor 11 kDa 11.0 ± 5.7 5.3 ± 1.1 0.5 2.1
4 Cystatin-SN IPI00305477   secreted cysteine-type endopeptidase inhibitor activity 16 kDa 13.5 ± 0.7 6.3 ± 2.5 0.5 2.2
5 IGKV3D-15 Myosin-reactive immunoglobulin light chain variable region IPI00549330     13 kDa 6.3 ± 0.4 2.8 ± 0.4 0.4 2.3
6 Nucleoside diphosphate kinase B IPI00026260 transcription regulation cytoplasm nucleus kinase 17 kDa 6.0 ± 3.5 2.5 ± 1.4 0.4 2.4
7 14-3-3 protein epsilon IPI00000816 host-virus interaction cytoplasm histone deacetylase binding 29 kDa 9.0 ± 1.4 3.5 ± 3.5 0.4 2.6
8 Prolactin-inducible protein IPI00022974   secreted actin binding 17 kDa 15.0 ± 12.0 5.3 ± 6.0 0.4 2.9
9 alpha-2-glycoprotein 1, zinc IPI00166729 immune response secreted transmembrane transporter activity 34 kDa 13.0 ± 2.8 4.5 ± 2.8 0.3 2.9
10 Polymeric immunoglobulin receptor IPI00004573   membrane secreted protein binding 83 kDa 76.0 ± 34.6 25.3 ± 31.5 0.3 3.0
11 Lipopolysaccharide-responsive and beige-like anchor protein IPI00002255   cell membrane protein binding 319 kDa 4.8 ± 4.6 1.5 ± 0.7 0.3 3.2
12 IGL@ protein IPI00555945     25 kDa 69.0 ± 27.6 21.5 ± 13.4 0.3 3.2
13 Heat shock protein beta-1 IPI00025512 stress response cytoplasm cytoskeleton nucleus identical protein binding 23 kDa 7.8 ± 1.1 2.3 ± 1.8 0.3 3.4
14 Glutathione S-transferase P IPI00219757 anti-apoptosis cytoplasm glutathione transferase activity 23 kDa 34.5 ± 30.4 10.0 ± 9.2 0.3 3.5
15 S100-A2 IPI00019869 endothelial cell migration   calcium ion binding 11 kDa 4.5 ± 0.7 1.3 ± 0.4 0.3 3.6
16 Glutathione transferase omega-1 IPI00019755   cytoplasm glutathione transferase activity 28 kDa 4.0 ± 1.4 1.0 ± 0.7 0.3 4.0
17 Carbonyl reductase [NADPH] 1 IPI00295386 oxidation reduction cytoplasm oxidoreductase 30 kDa 7.8 ± 3.2 1.3 ± 1.1 0.2 6.2
18 CRISP3 cDNA FLJ75207 IPI00004798   extracellular region   29 kDa 7.0 ± 7.8 1.0 ± 1.4 0.1 7.0
19 Isoform 1 of Serpin B3 IPI00022204   cytoplasm serine protease inhibitor 45 kDa 4.5 ± 2.1 0.5 ± 0.0 0.1 9.0
20 Aldo-keto reductase family 1 member B10 IPI00105407 oxidation reduction cytoplasm oxidoreductase 36 kDa 4.8 ± 3.2 0.3 ± 0.4 0.1 19.0