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Table 3 List of downregulated proteins in periodontitis GCF.

From: Identification of azurocidin as a potential periodontitis biomarker by a proteomic analysis of gingival crevicular fluid

#

Identified Proteins

Accession Number

Biological process

Cellular component

Molecular function

Molecular Weight

N

MP

MP/N fold

N/MP fold

1

Cystatin-A

IPI00032325

keratinocyte

cytoplasm

cysteine-type endopeptidase inhibitor activity

11 kDa

4.5 ± 3.5

2.3 ± 1.1

0.5

2.0

2

Thymidine phosphorylase

IPI00292858

chemotaxis

 

glycosyltransferase

50 kDa

7.5 ± 2.8

3.8 ± 0.4

0.5

2.0

3

Cystatin-B

IPI00021828

 

cytoplasm nucleus

protease inhibitor

11 kDa

11.0 ± 5.7

5.3 ± 1.1

0.5

2.1

4

Cystatin-SN

IPI00305477

 

secreted

cysteine-type endopeptidase inhibitor activity

16 kDa

13.5 ± 0.7

6.3 ± 2.5

0.5

2.2

5

IGKV3D-15 Myosin-reactive immunoglobulin light chain variable region

IPI00549330

   

13 kDa

6.3 ± 0.4

2.8 ± 0.4

0.4

2.3

6

Nucleoside diphosphate kinase B

IPI00026260

transcription regulation

cytoplasm nucleus

kinase

17 kDa

6.0 ± 3.5

2.5 ± 1.4

0.4

2.4

7

14-3-3 protein epsilon

IPI00000816

host-virus interaction

cytoplasm

histone deacetylase binding

29 kDa

9.0 ± 1.4

3.5 ± 3.5

0.4

2.6

8

Prolactin-inducible protein

IPI00022974

 

secreted

actin binding

17 kDa

15.0 ± 12.0

5.3 ± 6.0

0.4

2.9

9

alpha-2-glycoprotein 1, zinc

IPI00166729

immune response

secreted

transmembrane transporter activity

34 kDa

13.0 ± 2.8

4.5 ± 2.8

0.3

2.9

10

Polymeric immunoglobulin receptor

IPI00004573

 

membrane secreted

protein binding

83 kDa

76.0 ± 34.6

25.3 ± 31.5

0.3

3.0

11

Lipopolysaccharide-responsive and beige-like anchor protein

IPI00002255

 

cell membrane

protein binding

319 kDa

4.8 ± 4.6

1.5 ± 0.7

0.3

3.2

12

IGL@ protein

IPI00555945

   

25 kDa

69.0 ± 27.6

21.5 ± 13.4

0.3

3.2

13

Heat shock protein beta-1

IPI00025512

stress response

cytoplasm cytoskeleton nucleus

identical protein binding

23 kDa

7.8 ± 1.1

2.3 ± 1.8

0.3

3.4

14

Glutathione S-transferase P

IPI00219757

anti-apoptosis

cytoplasm

glutathione transferase activity

23 kDa

34.5 ± 30.4

10.0 ± 9.2

0.3

3.5

15

S100-A2

IPI00019869

endothelial cell migration

 

calcium ion binding

11 kDa

4.5 ± 0.7

1.3 ± 0.4

0.3

3.6

16

Glutathione transferase omega-1

IPI00019755

 

cytoplasm

glutathione transferase activity

28 kDa

4.0 ± 1.4

1.0 ± 0.7

0.3

4.0

17

Carbonyl reductase [NADPH] 1

IPI00295386

oxidation reduction

cytoplasm

oxidoreductase

30 kDa

7.8 ± 3.2

1.3 ± 1.1

0.2

6.2

18

CRISP3 cDNA FLJ75207

IPI00004798

 

extracellular region

 

29 kDa

7.0 ± 7.8

1.0 ± 1.4

0.1

7.0

19

Isoform 1 of Serpin B3

IPI00022204

 

cytoplasm

serine protease inhibitor

45 kDa

4.5 ± 2.1

0.5 ± 0.0

0.1

9.0

20

Aldo-keto reductase family 1 member B10

IPI00105407

oxidation reduction

cytoplasm

oxidoreductase

36 kDa

4.8 ± 3.2

0.3 ± 0.4

0.1

19.0