Table 1 Differentially regulated proteins by MPA in HEK-293 cells identified by mass spectrometry
Spot No | Acc | Mt/Mo(kDa) | Score | pIt/pIo | Pep | Protein name | FunctionBy KOGnitor NCBI | Expression change (in folds) |
|---|---|---|---|---|---|---|---|---|
6 | Q01105 | 33.4/37.0 | 154 | 4.23/4.14 | 3 | Protein SET | Replication, recombination and repair | 1.86*↓ |
9 | Q07021 | 31.3/31.0 | 141 | 4.74/4.5 | 3 | Complement component 1 Q subcomponent-binding protein, mitochondrial | Defense mechanisms | 1.58*↑ |
14 | P38117 | 27.8/25.5 | 181 | 8.24/9.18 | 6 | Electron transfer flavoprotein subunit beta | Energy production and conversion | 1.54*↑ |
15 | P47985 | 29.6/25.0 | 112 | 8.51/7.081 | 6 | Cytochrome b-c1 complex subunit Rieske, mitochondrial | Energy production and conversion | 3.71**↑ |
18 | Q06830 | 22.0/21.0 | 64 | 8. 27/8.14 | 2 | Peroxiredoxin-1 | Posttranslational modification, protein turnover, chaperones | 1.71**↑ |
22 | P16949 | 17.2/15.8 | 56 | 5.76/6.32 | 3 | Stathmin | General function prediction only | 1.50**↓ |
23 | O95881 | 19.1/16.0 | 123 | 5.24/5.89 | 4 | Thioredoxin domain-containing protein 12 | Cytoskeleton | 1.95*↑ |
24 | O14950 | 19.7/16.0 | 195 | 4.71/5.32 | 4 | Myosin regulatory light chain MRLC2 | Cytoskeleton | 3.41*↑ |
27 | Q96A08 | 14.1/14.5 | 51 | 10.31/7.0 | 2 | Histone H2B type 1-A | Chromatin structure and dynamics | 1.90*↓ |
28 | P62807 | 13.8/14.2 | 250 | 10.31/6.51 | 9 | Histone H2B type 1-C/E/F/G/I | Chromatin structure and dynamics | 1.58*↓ |
31 | P25398 | 14.5/13.0 | 89 | 6.81/7.10 | 3 | 40 S ribosomal protein S12 | Translation, ribosomal structure and biogenesis | 2.44*↓ |
34 | P07737 | 15.0/13.5 | 142 | 8.44/9.07 | 6 | Profilin-1 | Cytoskeleton | 1.51**↑ |