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Table 1 CEER can be utilized to profile tumor cells present in FNAs

From: Highly sensitive proximity mediated immunoassay reveals HER2 status conversion in the circulating tumor cells of metastatic breast cancer patients

 

HER2 Gene Amplification

HER1 (RTK/cell)

HER2 (RTK/cell)

pHER1 (RFU/μg)

pHER2 (RFU/μg)

BT474

Yes

3 × 104

2.2 × 106

6557

59860

MDA-MB-435

No

1.3 × 104

2.2 × 103

724

1301

MDA-MB-231

No

1.3 × 105

6 ×104

4619

3813

  1. The levels of HER1 and HER2 expression in cell lines used for xenograft models are shown as number of RTK expressed per cell (BT474, MDA-MB-435 and MDA-MB-231 [12–15, 22]). The degree of RTK activation in FNA samples obtained from xenograft models are shown in RFU per μg of tissue lysate.
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Proteome Science

ISSN: 1477-5956