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Table 3 Topmost five preferred residue pairs at the binding sites of protein-protein, protein-RNA and protein-DNA complexes

From: Sequence and structural features of binding site residues in protein-protein complexes: comparison with protein-nucleic acid complexes

Protein-protein

Protein-RNA

Protein-DNA

*B

ASP

TRP

CYS

TRP

SER

ARG

CYS

TRP

HIS

ARG

GLY

ARG

ILE

TRP

ASN

ARG

LYS

ARG

MET

TRP

ILE

TYR

ARG

ARG

MET

TYR

TRP

ARG

CYS

TRP

B*

CYS

TRP

HIS

TRP

ARG

SER

MET

TRP

HIS

HIS

ARG

GLY

TRP

PHE

HIS

ARG

ASN

TRP

TRP

HIS

LYS

HIS

ARG

LYS

TRP

MET

MET

TRP

ARG

ASN

  1. B: Binding. The binding residue are underlined.