SProt: sphere-based protein structure similarity algorithm

Table 1 Classification accuracy

Method	Family	Superfamily	Fold	RMSD	Cover	TM-score
SProt	90.4	96.9	98.6	4.14	81.1	0.63
Vorometric	90.7	94.9	97.6	2.43	87.2	0.74
PPM	88.3	94.5	97.5	n/a	n/a	n/a
db-iTM	86.6	95.8	98.2	n/a	n/a	n/a
Vorolign	86.4	92.4	97.7	1.90	76.3	0.74
CE	84.6	91.9	94.1	1.95	78.2	0.77
BLAST	48.9	52.5	52.8	–	–	–

The evaluation of classification accuracy was performed on the Vorolign dataset for different levels of the SCOP hierarchy (family, superfamily and fold). The table also describes average characteristics (RMSD, alignment cover and TM-score) of the most similar structures to the query. The values of the db-iTM method are taken from [13], and the values of the other compared methods are taken from [10].

ISSN: 1477-5956