Figure 1

Murine serum analysis using routine diagnostic methods. A) Clinical chemistry on an automated Roche system: The concentrations of serum creatinine, blood urea nitrogen, and total protein are stratified for all three experimental groups (WT n = 3; PLC n = 10; MMF n = 10) and presented as the mean and standard deviation. B) Drug concentrations: The serum pre-dose concentrations of mycophenolic acid (MPA) and mycophenolic acid glucuronide (MPAG) are presented for the treatment group (MMF n = 10) as the mean and standard deviation. C) Serum electrophoresis: The first fraction (1) stands for albumin, second (2) - alpha-1 globulins, third (3) - alpha-2 globulins, forth (4) - beta globulins and the fifth (5) gamma globulins. The rings show the mean relative proportion of each separated fraction for all three experimental groups (WT n = 3; PLC n = 6; MMF n = 8). Legends: wild-type 129/SvJ mice (WT); placebo COL4A3−/− mice (PLC); COL4A3−/− mice treated with 100 mg/kg mycophenolate mofetil per day (MMF); P < 0.05 using the Mann–Whitney-U test (*).