Table 2 Gene Ontology enrichment of up- and down-regulated protein lists. The most significant five enriched GO classes are shown for the up- and down-regulated proteins
From: Proteomic analysis of Pteropus alecto kidney cells in response to the viral mimic, Poly I:C
Regulation | GO ID | Gene Ontology | FDR q-value | Proteins contributing |
|---|---|---|---|---|
Up-regulated | GO:0006090 | pyruvate metabolic process | 6.40E-01 | Ldhb, Pgk1, Gapdh, Tpi1, Ldha, Pgam1, Pkm, Eno1 |
GO:0006733 | oxidoreduction coenzyme metabolic process | 3.49E-01 | Ldhb, Pgk1, Gapdh, Tpi1, Ldha, Pgam1, Pkm, Eno1, Taldo1, Tkt, Prdx5 | |
GO:0046496 | nicotinamide nucleotide metabolic process | 1.40E-01 | Ldhb, Pgk1, Gapdh, Tpi1, Ldha, Pgam1, Pkm, Eno1, Taldo1, Tkt, Prdx5 | |
GO:0006757 | ATP generation from ADP | 4.47E-01 | Pgk1, Gapdh, Tpi1, Ldha, Pgam1, Pkm, Eno1 | |
GO:0006096 | glycolytic process | 3.84E-01 | Pgk1, Gapdh, Tpi1, Ldha, Pgam1, Pkm, Eno1 | |
Down-regulated | GO:0006415 | translational termination | 1.31E-18 | Rps24, Rpl24, Rps3, Rpl19, Rpl18A, Rpl18, Rps16, Rpl13A, Rps15A, Rpl15, Rpl13, Rps18, Rpl7A, Rps8, Rpl34,Rps14, Rpl6, Rps28, Rpl4, Rps6, Rpl3 |
GO:0022411 | cellular component disassembly | 2.45E-18 | Same as above | |
GO:0043624 | cellular protein complex disassembly | 3.79E-18 | Same as above | |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 7.66E-18 | Same as above | |
GO:0006613 | cotranslational protein targeting to membrane | 6.13E-18 | Same as above |