Fig. 1

Mass spectrometry-based proteomics of hippocampus and cortex of in utero irradiated animals. Venn diagrams show the number of all and shared deregulated proteins in hippocampus (a) and cortex (b) exposed to 0.1, 0.5 and 1.0 Gy 6 months after in utero irradiation using global proteomics approach; n = 3. The comparison of proteomic profiles was performed on sham-irradiated control mice of the same age. The number above each dose represents the total number of deregulated proteins found at this dose. Altered learning- and memory-related signalling pathways at all doses using the Ingenuity Pathway Analysis software are shown (c). The high colour intensity indicates high significance (p-value) of the pathway; all coloured boxes have a p-value of ≤ 0.05 whereas white boxes have a p-value of > 0.05 and are thus not significantly altered. H: hippocampus; C: cortex