Fig. 2

Liquid chromatography – tandem mass spectrometry data. a Numerical distribution diagram showing the identified proteins in detergent resistant membrane microdomains in: control group (C: 1279 proteins), ApoE KO mice that received hyperlipidemic diet (A: 1233 proteins) and ApoE KO mice fed hyperlipidemic diet followed by statin treatment (At: 1239 proteins). Commonly identified (932 proteins) as well as uniquely attributed proteins (C: 191 proteins; A: 134 proteins and At: 160 proteins) are depicted. b The normalized ratio was plotted against the significance level for the proteins which were altered either in the hyperlipidemic condition (A/C: red circles) or the statin treatment in genetic hyperlipidemic stress (At/C: blue circles) or both of them. The horizontal line represents the minimum significance value threshold (P < 0.05), while the vertical lines denote the 1.5 fold alteration cut-off. The purple color signifies the superposition of red and blue circles. c Spatial quantitative scattering profile for the biological replicates of each group was performed for the control group (blue dots), ApoE KO mice fed hyperlipidemic diet (green dots) and ApoE KO mice that received hyperlipidemic diet followed by statin treatment (red dots)