Fig. 3

Actin dependent signal transduction pathways of identified and quantified detergent resistant membrane microdomains proteins. The interaction map comprises the currently discussed mass spectrometric identified proteins (red bordered boxes) and differentially expressed proteins (green filled red bordered boxes) and were integrated in the over-represented Regulation of actin cytoskeleton, Focal adhesion and Adherens junction signaling pathways. The complex signaling network represents the combination of map04810, map 04510 and map 04520 KEGG signaling pathways. Abbreviations for the discussed proteins: Ras: Ras-related protein R-Ras; MEK: mitogen-activated protein kinase kinase 1; F2RCD14: coagulation factor II, CD14 antigen; DOCK180: dedicator of cytokinesis protein; VWF: von Willebrand factor; Cav: caveolin; Gβγ: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; Arp2/3: Actin-related protein 2/3 complex subunit 1B and 3; PIR121: Cytoplasmic FMR1-interacting protein 1; PFN: profilin; CFN: Cofilin-1; ZYX: Zyxin; MLC: Myosin regulatory light polypeptide 9; MLCK: Myosin light chain kinase 2; mDia: Protein diaphanous homolog 1; ACTN: actinin: VCL: vinculin; TLN: talin; ITG: integrin; Rap-1: Ras-related protein Rap-1A; Rac: Ras-related C3 botulinum toxin substrate 1; ILK: Integrin-linked protein kinase; MLCP: Serine/threonine-protein phosphatase PP1-beta catalytic subunit; RhoA: Transforming protein RhoA; ERM: ezrin/radixin/moesin; GIT1: ARF GTPase-activating protein GIT1; Yes: Tyrosine-protein kinase Yes; IQGAP1: RasGTPase-activating-like protein IQGAP1; CKII: Casein kinase II subunit alpha; Gα12,13: Guanine nucleotide-binding protein subunit alpha-13