Table 1 Catalogue of differentially expressed proteins of DRM microdomains isolated from ApoE KO mice fed hyperlipidemic diet (A) and ApoE KO mice that received hyperlipidemic diet and statin treatment (At) against the control group (C). Table reports the SwissProt/UniProt Accession Number, protein description, molecular weight (MW), Mascot identification score, SIEVE normalized ratios of A over C and of At over C, their respective standard deviations and p-values
UNIPROT KEY | DESCRIPTION | MW (kDa) | Mascot score | A/C ratio | A/C std. dev. | A/C p value | At/C ratio | At/C std. dev. | At/C p value |
|---|---|---|---|---|---|---|---|---|---|
Q9JI91 | Alpha-actinin-2 | 103.8 | 353.78 | 2.875 | 0.825 | 1.84E-03 | 3.030 | 0.865 | 1.72E-03 |
P26231 | Catenin alpha-1 | 100.1 | 100 | 2.212 | 0.193 | 5.04E-04 | 2.230 | 0.226 | 5.03E-04 |
P63260 | Actin, cytoplasmic 2 | 41.8 | 5740.2 | 1.422 | 0.265 | 1.49E-02 | 2.386 | 0.305 | 1.10E-04 |
P60710 | Actin, cytoplasmic 1 | 41.7 | 5483.9 | 1.483 | 0.163 | 4.84E-05 | 1.785 | 0.184 | 1.80E-06 |
Q68FF6 | ARF GTPase-activating protein GIT1 | 85.2 | 62.49 | 1.590 | 0.610 | 6.57E-02 | 1.308 | 0.369 | 8.19E-02 |
Q60737 | Casein kinase II subunit alpha | 36.5 | 45.1 | 1.532 | 0.485 | 8.67E-02 | 1.267 | 0.274 | 5.76E-02 |
Q61739 | Integrin alpha-6 | 97.3 | 122.1 | 1.499 | 0.175 | 1.12E-03 | 1.022 | 0.066 | 2.41E-01 |
Q3V3R4 | Integrin alpha-1 | 130.7 | 236.53 | 1.325 | 0.065 | 3.38E-09 | 0.598 | 0.0308 | 3.26E-08 |
P62835 | Ras-related protein Rap-1A | 21.0 | 444.1 | 1.063 | 0.235 | 4.03E-01 | 0.747 | 0.156 | 8.04E-02 |
Q04736 | Tyrosine-protein kinase Yes | 92.38 | 60.6 | 1.008 | 0.090 | 5.49E-01 | 0.706 | 0.066 | 8.97E-05 |
Q9QUI0 | Transforming protein RhoA | 21.8 | 242.8 | 1.018 | 0.114 | 7.23E-01 | 0.741 | 0.083 | 1.42E-02 |
Q9QZQ1 | Afadin | 202.0 | 206.4 | 0.996 | 0.129 | 1.84E-03 | 0.559 | 0.051 | 2.40E-06 |
P09055 | Integrin beta-1 | 88.2 | 333.2 | 0.989 | 0.048 | 5.76E-01 | 0.575 | 0.021 | 5.21E-11 |
Q02248 | Catenin beta-1 | 85.4 | 2060.4 | 0.973 | 0.514 | 9.08E-01 | 0.740 | 0.255 | 1.97E-01 |
P27601 | Guanine nucleotide-binding protein subunit alpha-13 | 44.0 | 108.65 | 0.938 | 0.252 | 6.44E-01 | 0.550 | 0.230 | 3.39E-02 |
Q7TPR4 | Alpha-actinin-1 | 103.0 | 1300.8 | 0.940 | 0.229 | 3.63E-02 | 1.029 | 0.190 | 3.50E-02 |
P63001 | Ras-related C3 botulinum toxin substrate 1 | 21.4 | 111.49 | 0.932 | 0.057 | 2.94E-01 | 0.611 | 0.052 | 2.37E-06 |
P26041 | Moesin | 67.7 | 1657.9 | 0.913 | 0.024 | 2.01E-02 | 0.605 | 0.017 | 9.9E-20 |
P26040 | Ezrin | 69.4 | 594.85 | 0.904 | 0.068 | 3.22E-03 | 0.732 | 0.062 | 4.39E-04 |
P26043 | Radixin | 68.5 | 691.5 | 0.871 | 0.106 | 3.00E-01 | 0.694 | 0.053 | 3.37E-05 |
Q62470 | Integrin alpha-3 | 116.7 | 178.09 | 0.846 | 0.049 | 2.24E-02 | 0.543 | 0.0373 | 5.97E-09 |
Q61879 | Myosin-10 | 228.9 | 3486.6 | 0.843 | 0.028 | 2.04E-08 | 0.778 | 0.019 | 9.9E-20 |
A2ARA8 | Integrin alpha-8 | 117.5 | 69.83 | 0.803 | 0.232 | 2.51E-01 | 0.537 | 0.108 | 1.11E-02 |
P62141 | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | 37.2 | 61.83 | 0.779 | 0.124 | 5.84E-02 | 0.598 | 0.103 | 1.50E-02 |
Q8VDD5 | Myosin-9 | 226.2 | 7387 | 0.741 | 0.089 | 4.55E-03 | 0.742 | 0.056 | 2.71E-03 |
Q64727 | Vinculin | 16.6 | 2596.1 | 0.755 | 0.315 | 2.53E-01 | 0.685 | 0.301 | 1.69E-01 |
P26039 | Talin-1 | 269.7 | 3143 | 0.728 | 0.022 | 5.00E-10 | 0.684 | 0.020 | 2.19E-12 |
Q9JKF1 | RasGTPase-activating-like protein IQGAP1 | 188.7 | 188.6 | 0.696 | 0.186 | 6.47E-02 | 0.699 | 0.193 | 6.48E-02 |
O55222 | Integrin-linked protein kinase | 51.3 | 330.25 | 0.668 | 0.060 | 9.41E-05 | 0.704 | 0.045 | 1.05E-03 |