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Table 1 Catalogue of differentially expressed proteins of DRM microdomains isolated from ApoE KO mice fed hyperlipidemic diet (A) and ApoE KO mice that received hyperlipidemic diet and statin treatment (At) against the control group (C). Table reports the SwissProt/UniProt Accession Number, protein description, molecular weight (MW), Mascot identification score, SIEVE normalized ratios of A over C and of At over C, their respective standard deviations and p-values

From: Alteration of actin dependent signaling pathways associated with membrane microdomains in hyperlipidemia

UNIPROT KEY DESCRIPTION MW (kDa) Mascot score A/C ratio A/C std. dev. A/C p value At/C ratio At/C std. dev. At/C p value
Q9JI91 Alpha-actinin-2 103.8 353.78 2.875 0.825 1.84E-03 3.030 0.865 1.72E-03
P26231 Catenin alpha-1 100.1 100 2.212 0.193 5.04E-04 2.230 0.226 5.03E-04
P63260 Actin, cytoplasmic 2 41.8 5740.2 1.422 0.265 1.49E-02 2.386 0.305 1.10E-04
P60710 Actin, cytoplasmic 1 41.7 5483.9 1.483 0.163 4.84E-05 1.785 0.184 1.80E-06
Q68FF6 ARF GTPase-activating protein GIT1 85.2 62.49 1.590 0.610 6.57E-02 1.308 0.369 8.19E-02
Q60737 Casein kinase II subunit alpha 36.5 45.1 1.532 0.485 8.67E-02 1.267 0.274 5.76E-02
Q61739 Integrin alpha-6 97.3 122.1 1.499 0.175 1.12E-03 1.022 0.066 2.41E-01
Q3V3R4 Integrin alpha-1 130.7 236.53 1.325 0.065 3.38E-09 0.598 0.0308 3.26E-08
P62835 Ras-related protein Rap-1A 21.0 444.1 1.063 0.235 4.03E-01 0.747 0.156 8.04E-02
Q04736 Tyrosine-protein kinase Yes 92.38 60.6 1.008 0.090 5.49E-01 0.706 0.066 8.97E-05
Q9QUI0 Transforming protein RhoA 21.8 242.8 1.018 0.114 7.23E-01 0.741 0.083 1.42E-02
Q9QZQ1 Afadin 202.0 206.4 0.996 0.129 1.84E-03 0.559 0.051 2.40E-06
P09055 Integrin beta-1 88.2 333.2 0.989 0.048 5.76E-01 0.575 0.021 5.21E-11
Q02248 Catenin beta-1 85.4 2060.4 0.973 0.514 9.08E-01 0.740 0.255 1.97E-01
P27601 Guanine nucleotide-binding protein subunit alpha-13 44.0 108.65 0.938 0.252 6.44E-01 0.550 0.230 3.39E-02
Q7TPR4 Alpha-actinin-1 103.0 1300.8 0.940 0.229 3.63E-02 1.029 0.190 3.50E-02
P63001 Ras-related C3 botulinum toxin substrate 1 21.4 111.49 0.932 0.057 2.94E-01 0.611 0.052 2.37E-06
P26041 Moesin 67.7 1657.9 0.913 0.024 2.01E-02 0.605 0.017 9.9E-20
P26040 Ezrin 69.4 594.85 0.904 0.068 3.22E-03 0.732 0.062 4.39E-04
P26043 Radixin 68.5 691.5 0.871 0.106 3.00E-01 0.694 0.053 3.37E-05
Q62470 Integrin alpha-3 116.7 178.09 0.846 0.049 2.24E-02 0.543 0.0373 5.97E-09
Q61879 Myosin-10 228.9 3486.6 0.843 0.028 2.04E-08 0.778 0.019 9.9E-20
A2ARA8 Integrin alpha-8 117.5 69.83 0.803 0.232 2.51E-01 0.537 0.108 1.11E-02
P62141 Serine/threonine-protein phosphatase PP1-beta catalytic subunit 37.2 61.83 0.779 0.124 5.84E-02 0.598 0.103 1.50E-02
Q8VDD5 Myosin-9 226.2 7387 0.741 0.089 4.55E-03 0.742 0.056 2.71E-03
Q64727 Vinculin 16.6 2596.1 0.755 0.315 2.53E-01 0.685 0.301 1.69E-01
P26039 Talin-1 269.7 3143 0.728 0.022 5.00E-10 0.684 0.020 2.19E-12
Q9JKF1 RasGTPase-activating-like protein IQGAP1 188.7 188.6 0.696 0.186 6.47E-02 0.699 0.193 6.48E-02
O55222 Integrin-linked protein kinase 51.3 330.25 0.668 0.060 9.41E-05 0.704 0.045 1.05E-03