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Table 3 Distribution of CysC proteoforms concentrations by DM and CKD groups

From: The association of plasma cystatin C proteoforms with diabetic chronic kidney disease

  N1/N2/N3 Control DM CKD p-value
Native CysC (mg/L) 33/34/44 1.09 (0.71,1.35) 1.15(0.97,1.48) 1.59 (1.07, 2.02) <0.01a
CysC des-S (mg/L) 33/34/44 0.03 (0.025,0.046) 0.039 (0.03,0.05) 0.059 (0.035,0.08) <0.01b
CysC des-SSP (mg/L) 33/34/44 0.06 (0.04,0.09) 0.053 (0.02, 0.071) 0.094(0.035, 0.14) <0.01c
  1. Median (25th percentile, 75th percentile). Statistical significance defined with a p < 0.02. Groups compared with ANOVA followed by Tukey’s pairwise comparisons
  2. N1 = Control
  3. N2 = DM
  4. N3 = CKD
  5. aNative CysC
  6. In DM vs. controls, p = 0.6
  7. In CKD vs. DM, p = 0.02
  8. In CKD vs. controls, p = 0.001
  9. bCysC des-S
  10. In DM vs. controls, p = 0.8
  11. In CKD vs. DM, p = 0.002
  12. In CKD vs. controls, p = 0.0002
  13. cCysC des-SSP
  14. In DM vs. controls, p = 0.9
  15. In CKD vs. DM, p = 0.008
  16. In CKD vs. controls, p = 0.002