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Table 4 Association of CysC concentrations with eGFR

From: The association of plasma cystatin C proteoforms with diabetic chronic kidney disease

   Combined sample Control DM CKD
  N/N1/N2/N3 Regression coefficient Beta (SE) P-value Regression coefficient Beta (SE) P-value Regression coefficient Beta (SE) P-value Regression coefficient Beta (SE) P-value
Total CysC 107/33/34/40 −16.40 (17.62) <0.0001 2.47 (10.82) 0.82 −4.96 (7.66) 0.52 −10.09 (3.36) <0.01
CysC des-SSP 107/33/34/40 −245.96 (44.41) <0.0001 −83.46 (106.80) 0.44 −132.88 (116.49) 0.26 −177.17 (29.44) <0.001
CysC des-S 107/33/34/40 −486.92 (92.06) <0.0001 −375.06 (310.95) 0.24 −100.46 (213.44) 0.64 −281.68 (72.88) <0.001
Native CysC 107/33/34/40 −16.40 (4.03) <0.001 4.32 (11.60) 0.71 −4.86 (8.18) 0.56 −10.24 (3.86) 0.01
  1. Linear regression with eGFR as the dependent variable and total CysC, CysC des-SSP, CysC des-S, native CysC concentrations as the independent variables adjusted for age, sex and BMI. Type Ι error rate = 0.02 adjusted for multiple comparisons
  2. N = number of subjects in combined sample (control + DM + CKD)
  3. N1 = Control
  4. N2 = DM
  5. N3 = CKD