The association of plasma cystatin C proteoforms with diabetic chronic kidney disease

Table 4 Association of CysC concentrations with eGFR

		Combined sample		Control		DM		CKD
	N/N₁/N₂/N₃	Regression coefficient Beta (SE)	P-value	Regression coefficient Beta (SE)	P-value	Regression coefficient Beta (SE)	P-value	Regression coefficient Beta (SE)	P-value
Total CysC	107/33/34/40	−16.40 (17.62)	<0.0001	2.47 (10.82)	0.82	−4.96 (7.66)	0.52	−10.09 (3.36)	<0.01
CysC des-SSP	107/33/34/40	−245.96 (44.41)	<0.0001	−83.46 (106.80)	0.44	−132.88 (116.49)	0.26	−177.17 (29.44)	<0.001
CysC des-S	107/33/34/40	−486.92 (92.06)	<0.0001	−375.06 (310.95)	0.24	−100.46 (213.44)	0.64	−281.68 (72.88)	<0.001
Native CysC	107/33/34/40	−16.40 (4.03)	<0.001	4.32 (11.60)	0.71	−4.86 (8.18)	0.56	−10.24 (3.86)	0.01

Linear regression with eGFR as the dependent variable and total CysC, CysC des-SSP, CysC des-S, native CysC concentrations as the independent variables adjusted for age, sex and BMI. Type Ι error rate = 0.02 adjusted for multiple comparisons
N = number of subjects in combined sample (control + DM + CKD)
N₁ = Control
N₂ = DM
N₃ = CKD

ISSN: 1477-5956