Fig. 5

a to d presents the comparison of the solid angle values of the atoms at the average binding site of the drug Response mutants delE746_T751insV (RL = 1, a and c) and delE746_A750 (RL = 2, b and d), and the No-response ones delL747_K754insANKG (RL = 4) and S768I_V774M (RL = 3). The drug Response and No-response mutants are shown in blue and red, respectively. e and f show the statistics of the convex atoms and the atoms with SA > 0.7 at the average binding site of the 30 mutants. The mutants of each response level group are sorted in an ascending order by the number of convex atoms. Blue, red, green and magenta correspond to mutants with RL = 1, 2, 3 and 4