Table 3 Validation of pathways affected by in difference expression protein by the different metabolic detected by ¹H NMR (Y1 compared with Y2)

Y1 upregulated

Two-component system

1^a

2^b

Y2 upregulated

ABC transporters

2^c

9^d

Glycine, serine and threonine metabolism

-

4^g

Methane metabolism

-

5^h

Pentose phosphate pathway

-

1^l

Phenylalanine metabolism

-

4^k

Pyrimidine metabolism

1^e

5^f

Y1 and Y2 Co-regulated

Bacterial chemotaxis

-

-

Bacterial secretion system

-

-

Glycolysis / Gluconeogenesis

1ⁱ

2^j