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Table 4 Verify pathways affected by in difference expression protein by the different metabolic detected by 1H NMR (Y1 compared with Y3)

From: Multi-omics analysis on the pathogenicity of Enterobacter cloacae ENHKU01 isolated from sewage outfalls along the Ningbo coastline

The condition of regulated by proteins Pathways Upregulated Metabolites
Y1 Y3
Y3 upregulated Bacterial secretion system - -
Butanoate metabolism - 3a
Nitrogen metabolism - 1b
Bacterial chemotaxis - 1c
Phenylalanine metabolism - 4d
Tyrosine metabolism - 2e
Fructose and mannose metabolism - -
Methane metabolism - 5f
Oxidative phosphorylation - 3g
Pentose phosphate pathway - 1h
Glycine, serine and threonine metabolism - 6i
ABC transporters - 13j
Y1 and Y3 Co-regulated Pyruvate metabolism - 5k
Citrate cycle - 3l
Glutathione metabolism - 1m
Phosphotransferase system - 1n
RNA degradation - -
Nicotinate and nicotinamide metabolism -
Two-component system - 3p
Glycolysis/Gluconeogenesis - 2q
Glycerophospholipid metabolism 1r 2s
Pyrimidine metabolism - 4t
Purine metabolism - 5u
  1. aSuccinate, Fumarate, Pyruvate. bFormate. cAspartate. dPhenylalanine, Succinate, Fumarate, Pyruvate. eFumarate, Pyruvate. fGlycine, Acetate, Formate, Pyruvate, Methanol. gSuccinate, NAD+, Fumarate. hPyruvate. iAspartate, Betaine, Choline, Glycine, Pyruvate, Threonine. jAlanine, Aspartate, Betaine, Glycine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Choline, Succinate, Valine, Threonine. kSuccinate, Acetate, Formate, Fumarate, Pyruvate. lSuccinate, Fumarate, Pyruvate. mGlycine. nPyruvate. oAspartate, NAD+, Fumarate, Pyruvate, Nicotinate. pAspartate, Succinate, Fumarate. qAcetate, Pyruvate. rsn-Glycero-3-phosphocholine.sEthanolamine, Choline. tAlanine, Uracil, Cytosine, Uridine. uGlycine, Adenine, Adenosine, Hypoxanthine, Inosine