Multi-omics analysis on the pathogenicity of Enterobacter cloacae ENHKU01 isolated from sewage outfalls along the Ningbo coastline

Table 4 Verify pathways affected by in difference expression protein by the different metabolic detected by ¹H NMR (Y1 compared with Y3)

The condition of regulated by proteins	Pathways	Upregulated Metabolites
The condition of regulated by proteins	Pathways	Y1	Y3
Y3 upregulated	Bacterial secretion system	-	-
	Butanoate metabolism	-	3^a
	Nitrogen metabolism	-	1^b
	Bacterial chemotaxis	-	1^c
	Phenylalanine metabolism	-	4^d
	Tyrosine metabolism	-	2^e
	Fructose and mannose metabolism	-	-
	Methane metabolism	-	5^f
	Oxidative phosphorylation	-	3^g
	Pentose phosphate pathway	-	1^h
	Glycine, serine and threonine metabolism	-	6ⁱ
	ABC transporters	-	13^j
Y1 and Y3 Co-regulated	Pyruvate metabolism	-	5^k
	Citrate cycle	-	3^l
	Glutathione metabolism	-	1^m
	Phosphotransferase system	-	1ⁿ
	RNA degradation	-	-
	Nicotinate and nicotinamide metabolism	-	5°
	Two-component system	-	3^p
	Glycolysis/Gluconeogenesis	-	2^q
	Glycerophospholipid metabolism	1^r	2^s
	Pyrimidine metabolism	-	4^t
	Purine metabolism	-	5^u

^aSuccinate, Fumarate, Pyruvate. ^bFormate. ^cAspartate. ^dPhenylalanine, Succinate, Fumarate, Pyruvate. ^eFumarate, Pyruvate. ^fGlycine, Acetate, Formate, Pyruvate, Methanol. ^gSuccinate, NAD⁺, Fumarate. ^hPyruvate. ⁱAspartate, Betaine, Choline, Glycine, Pyruvate, Threonine. ^jAlanine, Aspartate, Betaine, Glycine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Choline, Succinate, Valine, Threonine. ^kSuccinate, Acetate, Formate, Fumarate, Pyruvate. ^lSuccinate, Fumarate, Pyruvate. ^mGlycine. ⁿPyruvate. ^oAspartate, NAD⁺, Fumarate, Pyruvate, Nicotinate. ^pAspartate, Succinate, Fumarate. ^qAcetate, Pyruvate. ^rsn-Glycero-3-phosphocholine.^sEthanolamine, Choline. ^tAlanine, Uracil, Cytosine, Uridine. ^uGlycine, Adenine, Adenosine, Hypoxanthine, Inosine

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