Table 4 Verify pathways affected by in difference expression protein by the different metabolic detected by ¹H NMR (Y1 compared with Y3)

Y3 upregulated

Bacterial secretion system

-

-

Butanoate metabolism

-

3^a

Nitrogen metabolism

-

1^b

Bacterial chemotaxis

-

1^c

Phenylalanine metabolism

-

4^d

Tyrosine metabolism

-

2^e

Fructose and mannose metabolism

-

-

Methane metabolism

-

5^f

Oxidative phosphorylation

-

3^g

Pentose phosphate pathway

-

1^h

Glycine, serine and threonine metabolism

-

6ⁱ

ABC transporters

-

13^j

Y1 and Y3 Co-regulated

Pyruvate metabolism

-

5^k

Citrate cycle

-

3^l

Glutathione metabolism

-

1^m

Phosphotransferase system

-

1ⁿ

RNA degradation

-

-

Nicotinate and nicotinamide metabolism

-

5°

Two-component system

-

3^p

Glycolysis/Gluconeogenesis

-

2^q

Glycerophospholipid metabolism

1^r

2^s

Pyrimidine metabolism

-

4^t

Purine metabolism

-

5^u