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Table 4 List of differentially expressed proteins in small intestinal mucosal samples from treatment group and control group

From: Proteome changes in the small intestinal mucosa of growing pigs with dietary supplementation of non-starch polysaccharide enzymes

Accessiona

Descriptionb

Gene symbol

Scorec

Pep. Nod

Log2 fold change

P-valuee

Biological process GO term

Transcriptional and translational regulation

 F1S419

Uncharacterized protein OS = Sus scrofa GN = SF3B3 PE = 4 SV = 2 - [F1S419_PIG]

None

85.61

3

−0.37

0.0007

RNA binding

 K9J4V0

U5 small nuclear ribonucleoprotein 200 kDa helicase OS = Sus scrofa GN = SNRNP200 PE = 2 SV = 1 - [K9J4V0_PIG]

SNRNP200

248.18

9

−0.32

0.0012

Nucleic acid binding

 F2Z5Q6

40S ribosomal protein S6 (Fragment) OS = Sus scrofa GN = RPS6 PE = 3 SV = 2 - [F2Z5Q6_PIG]

RPS6

140.42

4

−0.81

0.0013

Structural constituent of ribosome

 F1SD96

Uncharacterized protein (Fragment) OS = Sus scrofa GN = RAD23A PE = 4 SV = 1 - [F1SD96_PIG]

RAD23A

85.25

3

1.06

0.0026

Nucleotide excision repair

 F1S8K5

Uncharacterized protein OS = Sus scrofa GN = SUPT16H PE = 4 SV = 1 - [F1S8K5_PIG]

SUPT16H

35.43

2

−0.40

0.0028

RNA binding

 F1RZH4

Uncharacterized protein OS = Sus scrofa PE = 4 SV = 1 - [F1RZH4_PIG]

ADAM10

32.67

1

−0.82

0.0048

Structural constituent of ribosome

 F1SD98

Uncharacterized protein OS = Sus scrofa GN = TRMT1 PE = 4 SV = 2 - [F1SD98_PIG]

TRMT1

27.72

1

−0.30

0.0065

Poly(A) RNA binding

 I3LHZ6

Uncharacterized protein OS = Sus scrofa GN = DHX9 PE = 4 SV = 1 - [I3LHZ6_PIG]

DHX9

994.71

27

−0.30

0.0075

ATP-dependent RNA helicase activity

 F1SDV7

Uncharacterized protein (Fragment) OS = Sus scrofa GN = TOP1 PE = 4 SV = 1 - [F1SDV7_PIG]

TOP1

99.93

4

−0.44

0.0075

DNA binding

 P62802

Histone H4 OS = Sus scrofa PE = 1 SV = 2 - [H4_PIG]

None

358.11

7

−0.67

0.0103

DNA binding

 F1S1V1

Uncharacterized protein OS = Sus scrofa GN = SSB PE = 4 SV = 2 - [F1S1V1_PIG]

SSB

196.5

6

−0.73

0.0111

Nucleotide binding

 F1RS45

DNA topoisomerase 2 OS = Sus scrofa PE = 3 SV = 2 - [F1RS45_PIG]

TOP2B

116.62

6

−0.27

0.0117

DNA binding

 F1S1X3

Uncharacterized protein OS = Sus scrofa GN = NARS PE = 3 SV = 2 - [F1S1X3_PIG]

NARS

262.65

7

−0.30

0.0119

Nucleotide binding

 F2Z576

Histone H3 OS = Sus scrofa GN = LOC100525821 PE = 2 SV = 1 - [F2Z576_PIG]

HIST1H3E

159.44

6

−0.77

0.0120

DNA binding

 Q29194

Ribosomal protein S2 (Fragment) OS = Sus scrofa PE = 2 SV = 1 - [Q29194_PIG]

None

46.59

1

−0.45

0.0138

Structural constituent of ribosome

 I3LFV4

Uncharacterized protein OS = Sus scrofa GN = YBX1 PE = 4 SV = 1 - [I3LFV4_PIG]

YBX1

157.89

4

0.41

0.0148

DNA repair

 I3LIN8

Histone H2A OS = Sus scrofa GN = H2AFY PE = 3 SV = 1 - [I3LIN8_PIG]

H2AFY

224.89

6

−0.52

0.0149

Chromatin DNA binding

 B0FWK5

Ribosomal protein L5 OS = Sus scrofa GN = RPL5 PE = 2 SV = 1 - [B0FWK5_PIG]

RPL5

178.57

8

−0.34

0.0165

Structural constituent of ribosome

 I3LCI4

Uncharacterized protein OS = Sus scrofa GN = ZFR PE = 4 SV = 1 - [I3LCI4_PIG]

ZFR

41.93

2

−0.28

0.0167

Poly(A) RNA binding

 F1S8A5

Uncharacterized protein OS = Sus scrofa GN = MRPS26 PE = 4 SV = 1 - [F1S8A5_PIG]

MRPS26

38.63

1

−0.36

0.0181

Poly(A) RNA binding

 A5GFY4

Negative elongation factor D OS = Sus scrofa GN = NELFCD PE = 3 SV = 1 - [NELFD_PIG]

NELFCD

43.67

1

−0.32

0.0189

Negative regulation of transcription

 F1S5A8

Uncharacterized protein OS = Sus scrofa GN = DHX15 PE = 4 SV = 1 - [F1S5A8_PIG]

DHX15

259.43

8

−0.26

0.0198

ATP-dependent RNA helicase activity

 F1RRG9

Uncharacterized protein OS = Sus scrofa GN = SMARCA5 PE = 4 SV = 1 - [F1RRG9_PIG]

SMARCA5

99.44

3

−0.39

0.0201

DNA binding

 F1RGP1

Uncharacterized protein OS = Sus scrofa GN = MYBBP1A PE = 4 SV = 1 - [F1RGP1_PIG]

MYBBP1A

445.89

12

−0.50

0.0208

Poly(A) RNA binding

 F2Z5Q8

Uncharacterized protein OS = Sus scrofa GN = LOC100519675 PE = 4 SV = 1 - [F2Z5Q8_PIG]

RPL35A

57.33

2

−0.45

0.0209

Structural constituent of ribosome

 I3L7T6

Histone H2A OS = Sus scrofa GN = H2AFX PE = 3 SV = 1 - [I3L7T6_PIG]

H2AFX

357.7

7

−0.56

0.0231

DNA binding

 F1SMZ9

Uncharacterized protein (Fragment) OS = Sus scrofa GN = SF3B1 PE = 4 SV = 2 - [F1SMZ9_PIG]

SF3B1

267.33

9

−0.26

0.0245

mRNA binding

 F2Z5K9

Histone H3 OS = Sus scrofa GN = LOC100622412 PE = 3 SV = 1 - [F2Z5K9_PIG]

LOC100622412

178.75

6

−0.76

0.0270

DNA binding

 P53027

60S ribosomal protein L10a (Fragment) OS = Sus scrofa GN = RPL10A PE = 2 SV = 3 - [RL10A_PIG]

RPL10A

154.25

5

−0.34

0.0272

RNA binding

 K9IVG8

DEAD (Asp-Glu-Ala-Asp) box helicase 21 OS = Sus scrofa GN = DDX21 PE = 2 SV = 1 - [K9IVG8_PIG]

DDX21

44.62

1

−0.38

0.0292

RNA binding

 F2Z554

Uncharacterized protein OS = Sus scrofa GN = RPL30 PE = 3 SV = 1 - [F2Z554_PIG]

RPL30

105.87

4

−0.26

0.0323

RNA binding

 Q29195

60S ribosomal protein L10 OS = Sus scrofa GN = RPL10 PE = 2 SV = 3 - [RL10_PIG]

RPL10

105.8

4

−0.39

0.0350

Structural constituent of ribosome

 P67985

60S ribosomal protein L22 OS = Sus scrofa GN = RPL22 PE = 2 SV = 2 - [RL22_PIG]

RPL22

113.83

3

−0.48

0.0355

Structural constituent of ribosome

 I7GF95

Guanine nucleotide binding protein-like 1 OS = Sus scrofa GN = GNL1 PE = 4 SV = 1 - [I7GF95_PIG]

GNL1

58.56

1

−0.35

0.0371

Ribosome biogenesis

 F1S8L9

Uncharacterized protein OS = Sus scrofa GN = HNRNPU PE = 4 SV = 2 - [F1S8L9_PIG]

HNRNPU

883.61

23

−0.34

0.0377

Poly(A) RNA binding

 Q53DY5

Histone H1.3-like protein OS = Sus scrofa GN = LOC595122 PE = 2 SV = 1 - [Q53DY5_PIG]

HIST1H1D

251.92

7

1.29

0.0384

Chromatin DNA binding

 F1S2G3

Uncharacterized protein (Fragment) OS = Sus scrofa GN = TBCA PE = 4 SV = 1 - [F1S2G3_PIG]

TBCA

78.18

2

0.31

0.0389

Poly(A) RNA binding

 F2Z5P1

Histone H2A (Fragment) OS = Sus scrofa GN = H2AFV PE = 3 SV = 1 - [F2Z5P1_PIG]

LOC100512448

256.74

5

−0.43

0.0427

DNA binding

 F2Z553

Uncharacterized protein OS = Sus scrofa GN = EIF1 PE = 4 SV = 1 - [F2Z553_PIG]

EIF1

103.66

2

0.82

0.0437

Translation initiation factor activity

 F2Z5L5

Histone H2A OS = Sus scrofa GN = HIST2H2AC PE = 3 SV = 1 - [F2Z5L5_PIG]

HIST2H2AC

322.1

5

−0.62

0.0448

DNA binding

Redox homeostasis and detoxification

 F1SKJ2

Uncharacterized protein OS = Sus scrofa GN = TXN2 PE = 4 SV = 1 - [F1SKJ2_PIG]

TXN2

29.86

1

0.39

0.0043

Cell redox homeostasis

 F1SGS9

Catalase OS = Sus scrofa GN = CAT PE = 3 SV = 1 - [F1SGS9_PIG]

CAT

923.56

23

0.58

0.0151

Protect cells from the toxic effects of hydrogen peroxide

 I3LDJ8

Uncharacterized protein OS = Sus scrofa PE = 3 SV = 1 - [I3LDJ8_PIG]

None

303.51

10

0.77

0.0202

Oxidoreductase activity

 P12309

Glutaredoxin-1 OS = Sus scrofa GN = GLRX PE = 1 SV = 2 - [GLRX1_PIG]

GLRX

277.83

6

0.64

0.0208

Cell redox homeostasis

 F1SCF9

Uncharacterized protein (Fragment) OS = Sus scrofa GN = TECR PE = 4 SV = 2 - [F1SCF9_PIG]

TECR

38.34

1

−0.37

0.0242

Oxidoreductase activity

 A5J2A8

Thioredoxin (Fragment) OS = Sus scrofa GN = TRX PE = 4 SV = 1 - [A5J2A8_PIG]

TRX

128.36

3

0.34

0.0303

Cell redox homeostasis

 F1SMY1

Uncharacterized protein OS = Sus scrofa GN = TMX3 PE = 4 SV = 2 - [F1SMY1_PIG]

TMX3

39.1

2

0.30

0.0345

Cell redox homeostasis

 P16549

Dimethylaniline monooxygenase [N-oxide-forming] 1 OS = Sus scrofa GN = FMO1 PE = 1 SV = 3 - [FMO1_PIG]

FMO1

39.55

2

1.64

0.0084

Oxidative metabolism of a variety of xenobiotics

 P04178

Superoxide dismutase [Cu-Zn] OS = Sus scrofa GN = SOD1 PE = 1 SV = 2 - [SODC_PIG]

SOD1

459.04

9

0.35

0.0424

Superoxide dismutase activity

Immune response and inflammation

 A3FJ41

MHC class I antigen (Fragment) OS = Sus scrofa GN = SLA-1 PE = 4 SV = 1 - [A3FJ41_PIG]

SLA-1

120.03

5

0.35

0.0050

Immune response

 F1RGC8

Uncharacterized protein OS = Sus scrofa GN = NLRP6 PE = 4 SV = 3 - [F1RGC8_PIG]

NLRP6

119.58

4

−0.32

0.0061

Activation of NF-κB

 F1RFM7

Uncharacterized protein OS = Sus scrofa GN = AIMP2 PE = 4 SV = 1 - [F1RFM7_PIG]

AIMP2

232.75

6

−0.29

0.0076

Metabolism of xenobiotics

 A2SZV5

Tax1 binding protein 3 (Fragment) OS = Sus scrofa PE = 4 SV = 1 - [A2SZV5_PIG]

None

55.14

1

0.29

0.0133

Negative regulation of NF-κB

 B8XX91

DNA-dependent activator of IFN-regulatory factor OS = Sus scrofa GN = DAI PE = 2 SV = 1 - [B8XX91_PIG]

DAI

100.5

4

0.70

0.0137

Innate immune responses

 Q8WNQ7

N-acetylgalactosamine-6-sulfatase OS = Sus scrofa GN = GALNS PE = 2 SV = 1 - [GALNS_PIG]

GALNS

52.52

1

0.60

0.0311

Degradation of the glycosaminoglycans keratan sulfate

 B8XTR8

Granzyme H OS = Sus scrofa GN = gzmH PE = 2 SV = 1 - [B8XTR8_PIG]

gzmH

168.84

6

−0.67

0.0272

Serine-type endopeptidase activity

 A5GFQ5

Protein canopy homolog 3 OS = Sus scrofa GN = CNPY3 PE = 3 SV = 1 - [CNPY3_PIG]

CNPY3

40.13

2

−0.63

0.0376

Receptor binding for proper TLR folding

Energy metabolism

 Q1ACV5

Transporter associated with antigen processing 1 OS = Sus scrofa PE = 2 SV = 1 - [Q1ACV5_PIG]

None

298.67

7

−0.32

0.0030

Triggers ATP hydrolysis

 F1RIG0

Uncharacterized protein (Fragment) OS = Sus scrofa PE = 4 SV = 1 - [F1RIG0_PIG]

None

47.28

2

−0.27

0.0169

ATP binding

 Q7SIB7

Phosphoglycerate kinase 1 OS = Sus scrofa GN = PGK1 PE = 1 SV = 3 - [PGK1_PIG]

PGK1

850.39

23

0.30

0.0160

Conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate

 H9BYW2

Acyl-coenzyme A oxidase OS = Sus scrofa GN = ACOX1 PE = 2 SV = 1 - [H9BYW2_PIG]

ACOX1

370.35

10

0.91

0.0200

Fatty acid beta-oxidation

 I3LEN7

Uncharacterized protein OS = Sus scrofa GN = ALDH1L1 PE = 3 SV = 1 - [I3LEN7_PIG]

ALDH1L1

49.04

2

0.40

0.0245

Formate oxidation

 F1S0Y8

Uncharacterized protein OS = Sus scrofa GN = ADH4 PE = 3 SV = 2 - [F1S0Y8_PIG]

ADH4

40.7

2

0.67

0.0309

Oxidation of long-chain aliphatic alcohols

 A7UIU7

ATP citrate lyase OS = Sus scrofa GN = ACL PE = 2 SV = 1 - [A7UIU7_PIG]

ACL

468.98

14

−0.38

0.0374

ATP binding

Protein metabolism and modification

 F1RIF3

Uncharacterized protein OS = Sus scrofa GN = FAH PE = 4 SV = 1 - [F1RIF3_PIG]

FAH

38.37

2

0.39

0.0010

Catabolism of the amino acid phenylalanine

 Q9GK25

Peptidyl-prolyl cis-trans isomerase (Fragment) OS = Sus scrofa PE = 2 SV = 1 - [Q9GK25_PIG]

None

266.1

7

1.43

0.0025

Accelerate the folding of proteins

 I3L739

Uncharacterized protein OS = Sus scrofa GN = JMJD6 PE = 4 SV = 1 - [I3L739_PIG]

JMJD6

39.99

1

−0.29

0.0193

Protein hydroxylases

 I3LK37

Uncharacterized protein (Fragment) OS = Sus scrofa PE = 3 SV = 1 - [I3LK37_PIG]

GALNT7

33.39

2

−0.30

0.0248

Protein glycosylation

 F1RNR6

4-hydroxyphenylpyruvate dioxygenase OS = Sus scrofa GN = HPD PE = 3 SV = 2 - [F1RNR6_PIG]

HPD

31

1

0.35

0.0391

Aromatic amino acid family metabolic process

Lipid metabolism

 I3LM15

Uncharacterized protein OS = Sus scrofa GN = AGPS PE = 4 SV = 1 - [I3LM15_PIG]

AGPS

48.77

1

−0.36

0.0019

Lipid biosynthetic process

 Q9GJX2

Diazepam binding inhibitor (Fragment) OS = Sus scrofa GN = DBI PE = 2 SV = 1 - [Q9GJX2_PIG]

DBI

80.13

3

0.91

0.0057

Long-chain fatty acyl-CoA binding, triglyceride metabolic process

 P27917

Apolipoprotein C-III OS = Sus scrofa GN = APOC3 PE = 1 SV = 2 - [APOC3_PIG]

APOC3

226.39

7

0.78

0.0241

High-density lipoprotein particle receptor binding

Cell cytoskeleton

 P10668

Cofilin-1 OS = Sus scrofa GN = CFL1 PE = 1 SV = 3 - [COF1_PIG]

CFL1

704.02

15

0.31

0.0059

Cytoskeleton organization

 Q5G6W0

Cofilin-2 (Fragment) OS = Sus scrofa PE = 2 SV = 1 - [Q5G6W0_PIG]

CFL1

48.67

2

0.43

0.0073

Cytoskeleton organization

 B5APV0

Actin-related protein 2/3 complex subunit 5 OS = Sus scrofa GN = ARPC5 PE = 2 SV = 1 - [B5APV0_PIG]

ARPC5

170.99

6

0.30

0.0167

Structural constituent of cytoskeleton

Miscellaneous

 Q9TSA7

Calmodulin (Fragments) OS = Sus scrofa PE = 4 SV = 1 - [Q9TSA7_PIG]

None

108.72

4

1.11

0.0008

Calcium ion binding

 K7GKQ1

Uncharacterized protein OS = Sus scrofa GN = RAB9A PE = 3 SV = 1 - [K7GKQ1_PIG]

RAB9A

26.6

1

−0.40

0.0071

Cytoskeletal signaling

 F1RKI3

Uncharacterized protein OS = Sus scrofa GN = HINT1 PE = 4 SV = 1 - [F1RKI3_PIG]

HINT1

80.55

3

0.32

0.0073

Tumor suppressing

 I3LSY0

Uncharacterized protein OS = Sus scrofa GN = ACSM4 PE = 4 SV = 1 - [I3LSY0_PIG]

ACSM4

21.13

1

0.86

0.0179

Catalytic activity

 D0G6R8

Phosphatidate cytidylyltransferase OS = Sus scrofa GN = CDS2 PE = 2 SV = 1 - [D0G6R8_PIG]

CDS2

33.01

1

−0.39

0.0192

Synthesis of phosphatidylglycerol

 Q95332

Betaine--homocysteine S-methyltransferase 1 (Fragment) OS = Sus scrofa GN = BHMT PE = 1 SV = 3 - [BHMT1_PIG]

BHMT

110.41

4

1.10

0.0193

Regulation of homocysteine metabolism

 F1RS34

Uncharacterized protein OS = Sus scrofa GN = GAPVD1 PE = 4 SV = 2 - [F1RS34_PIG]

GAPVD1

22.69

1

−0.40

0.0207

Signal transduction

 F1ST01

Uncharacterized protein OS = Sus scrofa GN = SELENBP1 PE = 4 SV = 1 - [F1ST01_PIG]

SELENBP1

936.42

22

0.33

0.0209

Selenium binding

 Q9TV62

Myosin-4 OS = Sus scrofa GN = MYH4 PE = 2 SV = 1 - [MYH4_PIG]

MYH4

192.94

7

−0.83

0.0336

Motor activity

 F1RN91

Uncharacterized protein (Fragment) OS = Sus scrofa PE = 4 SV = 2 - [F1RN91_PIG]

MYO18A

35.04

2

0.28

0.0355

Cell migration

 F1RPC8

Uncharacterized protein OS = Sus scrofa GN = CRYM PE = 4 SV = 2 - [F1RPC8_PIG]

CRYM

59.33

2

0.49

0.0392

Thyroid hormone binding

 F2Z5W6

Uncharacterized protein OS = Sus scrofa GN = LAMTOR1 PE = 4 SV = 1 - [F2Z5W6_PIG]

LAMTOR1

26.54

1

−0.37

0.0410

Guanyl-nucleotide exchange factor activity

 Q29069

Myosin light chain OS = Sus scrofa PE = 2 SV = 2 - [Q29069_PIG]

None

58.61

3

−0.38

0.0458

Calcium ion binding

 O19175

Casein kinase I isoform alpha (Fragment) OS = Sus scrofa GN = CSNK1A1 PE = 2 SV = 1 - [KC1A_PIG]

CSNK1A1

51.13

1

−0.44

0.0473

Protein kinase activity

 N0E654

Casein kinase II b subunit splicing isoform 476 (Fragment) OS = Sus scrofa GN = Csnk2b PE = 2 SV = 1 - [N0E654_PIG]

Csnk2b

63.97

2

−0.27

0.0039

Cell proliferation and cell differentiation

  1. aUniprot_ Sus scrofa_9823 database accession number
  2. bThe name of the protein exclusive of the identifier that appears in the database
  3. cThe sum of the scores of the individual peptides
  4. dThe number of distinct peptide sequences in the protein group
  5. eDifferential protein expression in the treatment group was presented as a log2 fold change relative to the control group