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Table 4 List of differentially expressed proteins in small intestinal mucosal samples from treatment group and control group

From: Proteome changes in the small intestinal mucosa of growing pigs with dietary supplementation of non-starch polysaccharide enzymes

Accessiona Descriptionb Gene symbol Scorec Pep. Nod Log2 fold change P-valuee Biological process GO term
Transcriptional and translational regulation
 F1S419 Uncharacterized protein OS = Sus scrofa GN = SF3B3 PE = 4 SV = 2 - [F1S419_PIG] None 85.61 3 −0.37 0.0007 RNA binding
 K9J4V0 U5 small nuclear ribonucleoprotein 200 kDa helicase OS = Sus scrofa GN = SNRNP200 PE = 2 SV = 1 - [K9J4V0_PIG] SNRNP200 248.18 9 −0.32 0.0012 Nucleic acid binding
 F2Z5Q6 40S ribosomal protein S6 (Fragment) OS = Sus scrofa GN = RPS6 PE = 3 SV = 2 - [F2Z5Q6_PIG] RPS6 140.42 4 −0.81 0.0013 Structural constituent of ribosome
 F1SD96 Uncharacterized protein (Fragment) OS = Sus scrofa GN = RAD23A PE = 4 SV = 1 - [F1SD96_PIG] RAD23A 85.25 3 1.06 0.0026 Nucleotide excision repair
 F1S8K5 Uncharacterized protein OS = Sus scrofa GN = SUPT16H PE = 4 SV = 1 - [F1S8K5_PIG] SUPT16H 35.43 2 −0.40 0.0028 RNA binding
 F1RZH4 Uncharacterized protein OS = Sus scrofa PE = 4 SV = 1 - [F1RZH4_PIG] ADAM10 32.67 1 −0.82 0.0048 Structural constituent of ribosome
 F1SD98 Uncharacterized protein OS = Sus scrofa GN = TRMT1 PE = 4 SV = 2 - [F1SD98_PIG] TRMT1 27.72 1 −0.30 0.0065 Poly(A) RNA binding
 I3LHZ6 Uncharacterized protein OS = Sus scrofa GN = DHX9 PE = 4 SV = 1 - [I3LHZ6_PIG] DHX9 994.71 27 −0.30 0.0075 ATP-dependent RNA helicase activity
 F1SDV7 Uncharacterized protein (Fragment) OS = Sus scrofa GN = TOP1 PE = 4 SV = 1 - [F1SDV7_PIG] TOP1 99.93 4 −0.44 0.0075 DNA binding
 P62802 Histone H4 OS = Sus scrofa PE = 1 SV = 2 - [H4_PIG] None 358.11 7 −0.67 0.0103 DNA binding
 F1S1V1 Uncharacterized protein OS = Sus scrofa GN = SSB PE = 4 SV = 2 - [F1S1V1_PIG] SSB 196.5 6 −0.73 0.0111 Nucleotide binding
 F1RS45 DNA topoisomerase 2 OS = Sus scrofa PE = 3 SV = 2 - [F1RS45_PIG] TOP2B 116.62 6 −0.27 0.0117 DNA binding
 F1S1X3 Uncharacterized protein OS = Sus scrofa GN = NARS PE = 3 SV = 2 - [F1S1X3_PIG] NARS 262.65 7 −0.30 0.0119 Nucleotide binding
 F2Z576 Histone H3 OS = Sus scrofa GN = LOC100525821 PE = 2 SV = 1 - [F2Z576_PIG] HIST1H3E 159.44 6 −0.77 0.0120 DNA binding
 Q29194 Ribosomal protein S2 (Fragment) OS = Sus scrofa PE = 2 SV = 1 - [Q29194_PIG] None 46.59 1 −0.45 0.0138 Structural constituent of ribosome
 I3LFV4 Uncharacterized protein OS = Sus scrofa GN = YBX1 PE = 4 SV = 1 - [I3LFV4_PIG] YBX1 157.89 4 0.41 0.0148 DNA repair
 I3LIN8 Histone H2A OS = Sus scrofa GN = H2AFY PE = 3 SV = 1 - [I3LIN8_PIG] H2AFY 224.89 6 −0.52 0.0149 Chromatin DNA binding
 B0FWK5 Ribosomal protein L5 OS = Sus scrofa GN = RPL5 PE = 2 SV = 1 - [B0FWK5_PIG] RPL5 178.57 8 −0.34 0.0165 Structural constituent of ribosome
 I3LCI4 Uncharacterized protein OS = Sus scrofa GN = ZFR PE = 4 SV = 1 - [I3LCI4_PIG] ZFR 41.93 2 −0.28 0.0167 Poly(A) RNA binding
 F1S8A5 Uncharacterized protein OS = Sus scrofa GN = MRPS26 PE = 4 SV = 1 - [F1S8A5_PIG] MRPS26 38.63 1 −0.36 0.0181 Poly(A) RNA binding
 A5GFY4 Negative elongation factor D OS = Sus scrofa GN = NELFCD PE = 3 SV = 1 - [NELFD_PIG] NELFCD 43.67 1 −0.32 0.0189 Negative regulation of transcription
 F1S5A8 Uncharacterized protein OS = Sus scrofa GN = DHX15 PE = 4 SV = 1 - [F1S5A8_PIG] DHX15 259.43 8 −0.26 0.0198 ATP-dependent RNA helicase activity
 F1RRG9 Uncharacterized protein OS = Sus scrofa GN = SMARCA5 PE = 4 SV = 1 - [F1RRG9_PIG] SMARCA5 99.44 3 −0.39 0.0201 DNA binding
 F1RGP1 Uncharacterized protein OS = Sus scrofa GN = MYBBP1A PE = 4 SV = 1 - [F1RGP1_PIG] MYBBP1A 445.89 12 −0.50 0.0208 Poly(A) RNA binding
 F2Z5Q8 Uncharacterized protein OS = Sus scrofa GN = LOC100519675 PE = 4 SV = 1 - [F2Z5Q8_PIG] RPL35A 57.33 2 −0.45 0.0209 Structural constituent of ribosome
 I3L7T6 Histone H2A OS = Sus scrofa GN = H2AFX PE = 3 SV = 1 - [I3L7T6_PIG] H2AFX 357.7 7 −0.56 0.0231 DNA binding
 F1SMZ9 Uncharacterized protein (Fragment) OS = Sus scrofa GN = SF3B1 PE = 4 SV = 2 - [F1SMZ9_PIG] SF3B1 267.33 9 −0.26 0.0245 mRNA binding
 F2Z5K9 Histone H3 OS = Sus scrofa GN = LOC100622412 PE = 3 SV = 1 - [F2Z5K9_PIG] LOC100622412 178.75 6 −0.76 0.0270 DNA binding
 P53027 60S ribosomal protein L10a (Fragment) OS = Sus scrofa GN = RPL10A PE = 2 SV = 3 - [RL10A_PIG] RPL10A 154.25 5 −0.34 0.0272 RNA binding
 K9IVG8 DEAD (Asp-Glu-Ala-Asp) box helicase 21 OS = Sus scrofa GN = DDX21 PE = 2 SV = 1 - [K9IVG8_PIG] DDX21 44.62 1 −0.38 0.0292 RNA binding
 F2Z554 Uncharacterized protein OS = Sus scrofa GN = RPL30 PE = 3 SV = 1 - [F2Z554_PIG] RPL30 105.87 4 −0.26 0.0323 RNA binding
 Q29195 60S ribosomal protein L10 OS = Sus scrofa GN = RPL10 PE = 2 SV = 3 - [RL10_PIG] RPL10 105.8 4 −0.39 0.0350 Structural constituent of ribosome
 P67985 60S ribosomal protein L22 OS = Sus scrofa GN = RPL22 PE = 2 SV = 2 - [RL22_PIG] RPL22 113.83 3 −0.48 0.0355 Structural constituent of ribosome
 I7GF95 Guanine nucleotide binding protein-like 1 OS = Sus scrofa GN = GNL1 PE = 4 SV = 1 - [I7GF95_PIG] GNL1 58.56 1 −0.35 0.0371 Ribosome biogenesis
 F1S8L9 Uncharacterized protein OS = Sus scrofa GN = HNRNPU PE = 4 SV = 2 - [F1S8L9_PIG] HNRNPU 883.61 23 −0.34 0.0377 Poly(A) RNA binding
 Q53DY5 Histone H1.3-like protein OS = Sus scrofa GN = LOC595122 PE = 2 SV = 1 - [Q53DY5_PIG] HIST1H1D 251.92 7 1.29 0.0384 Chromatin DNA binding
 F1S2G3 Uncharacterized protein (Fragment) OS = Sus scrofa GN = TBCA PE = 4 SV = 1 - [F1S2G3_PIG] TBCA 78.18 2 0.31 0.0389 Poly(A) RNA binding
 F2Z5P1 Histone H2A (Fragment) OS = Sus scrofa GN = H2AFV PE = 3 SV = 1 - [F2Z5P1_PIG] LOC100512448 256.74 5 −0.43 0.0427 DNA binding
 F2Z553 Uncharacterized protein OS = Sus scrofa GN = EIF1 PE = 4 SV = 1 - [F2Z553_PIG] EIF1 103.66 2 0.82 0.0437 Translation initiation factor activity
 F2Z5L5 Histone H2A OS = Sus scrofa GN = HIST2H2AC PE = 3 SV = 1 - [F2Z5L5_PIG] HIST2H2AC 322.1 5 −0.62 0.0448 DNA binding
Redox homeostasis and detoxification
 F1SKJ2 Uncharacterized protein OS = Sus scrofa GN = TXN2 PE = 4 SV = 1 - [F1SKJ2_PIG] TXN2 29.86 1 0.39 0.0043 Cell redox homeostasis
 F1SGS9 Catalase OS = Sus scrofa GN = CAT PE = 3 SV = 1 - [F1SGS9_PIG] CAT 923.56 23 0.58 0.0151 Protect cells from the toxic effects of hydrogen peroxide
 I3LDJ8 Uncharacterized protein OS = Sus scrofa PE = 3 SV = 1 - [I3LDJ8_PIG] None 303.51 10 0.77 0.0202 Oxidoreductase activity
 P12309 Glutaredoxin-1 OS = Sus scrofa GN = GLRX PE = 1 SV = 2 - [GLRX1_PIG] GLRX 277.83 6 0.64 0.0208 Cell redox homeostasis
 F1SCF9 Uncharacterized protein (Fragment) OS = Sus scrofa GN = TECR PE = 4 SV = 2 - [F1SCF9_PIG] TECR 38.34 1 −0.37 0.0242 Oxidoreductase activity
 A5J2A8 Thioredoxin (Fragment) OS = Sus scrofa GN = TRX PE = 4 SV = 1 - [A5J2A8_PIG] TRX 128.36 3 0.34 0.0303 Cell redox homeostasis
 F1SMY1 Uncharacterized protein OS = Sus scrofa GN = TMX3 PE = 4 SV = 2 - [F1SMY1_PIG] TMX3 39.1 2 0.30 0.0345 Cell redox homeostasis
 P16549 Dimethylaniline monooxygenase [N-oxide-forming] 1 OS = Sus scrofa GN = FMO1 PE = 1 SV = 3 - [FMO1_PIG] FMO1 39.55 2 1.64 0.0084 Oxidative metabolism of a variety of xenobiotics
 P04178 Superoxide dismutase [Cu-Zn] OS = Sus scrofa GN = SOD1 PE = 1 SV = 2 - [SODC_PIG] SOD1 459.04 9 0.35 0.0424 Superoxide dismutase activity
Immune response and inflammation
 A3FJ41 MHC class I antigen (Fragment) OS = Sus scrofa GN = SLA-1 PE = 4 SV = 1 - [A3FJ41_PIG] SLA-1 120.03 5 0.35 0.0050 Immune response
 F1RGC8 Uncharacterized protein OS = Sus scrofa GN = NLRP6 PE = 4 SV = 3 - [F1RGC8_PIG] NLRP6 119.58 4 −0.32 0.0061 Activation of NF-κB
 F1RFM7 Uncharacterized protein OS = Sus scrofa GN = AIMP2 PE = 4 SV = 1 - [F1RFM7_PIG] AIMP2 232.75 6 −0.29 0.0076 Metabolism of xenobiotics
 A2SZV5 Tax1 binding protein 3 (Fragment) OS = Sus scrofa PE = 4 SV = 1 - [A2SZV5_PIG] None 55.14 1 0.29 0.0133 Negative regulation of NF-κB
 B8XX91 DNA-dependent activator of IFN-regulatory factor OS = Sus scrofa GN = DAI PE = 2 SV = 1 - [B8XX91_PIG] DAI 100.5 4 0.70 0.0137 Innate immune responses
 Q8WNQ7 N-acetylgalactosamine-6-sulfatase OS = Sus scrofa GN = GALNS PE = 2 SV = 1 - [GALNS_PIG] GALNS 52.52 1 0.60 0.0311 Degradation of the glycosaminoglycans keratan sulfate
 B8XTR8 Granzyme H OS = Sus scrofa GN = gzmH PE = 2 SV = 1 - [B8XTR8_PIG] gzmH 168.84 6 −0.67 0.0272 Serine-type endopeptidase activity
 A5GFQ5 Protein canopy homolog 3 OS = Sus scrofa GN = CNPY3 PE = 3 SV = 1 - [CNPY3_PIG] CNPY3 40.13 2 −0.63 0.0376 Receptor binding for proper TLR folding
Energy metabolism
 Q1ACV5 Transporter associated with antigen processing 1 OS = Sus scrofa PE = 2 SV = 1 - [Q1ACV5_PIG] None 298.67 7 −0.32 0.0030 Triggers ATP hydrolysis
 F1RIG0 Uncharacterized protein (Fragment) OS = Sus scrofa PE = 4 SV = 1 - [F1RIG0_PIG] None 47.28 2 −0.27 0.0169 ATP binding
 Q7SIB7 Phosphoglycerate kinase 1 OS = Sus scrofa GN = PGK1 PE = 1 SV = 3 - [PGK1_PIG] PGK1 850.39 23 0.30 0.0160 Conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate
 H9BYW2 Acyl-coenzyme A oxidase OS = Sus scrofa GN = ACOX1 PE = 2 SV = 1 - [H9BYW2_PIG] ACOX1 370.35 10 0.91 0.0200 Fatty acid beta-oxidation
 I3LEN7 Uncharacterized protein OS = Sus scrofa GN = ALDH1L1 PE = 3 SV = 1 - [I3LEN7_PIG] ALDH1L1 49.04 2 0.40 0.0245 Formate oxidation
 F1S0Y8 Uncharacterized protein OS = Sus scrofa GN = ADH4 PE = 3 SV = 2 - [F1S0Y8_PIG] ADH4 40.7 2 0.67 0.0309 Oxidation of long-chain aliphatic alcohols
 A7UIU7 ATP citrate lyase OS = Sus scrofa GN = ACL PE = 2 SV = 1 - [A7UIU7_PIG] ACL 468.98 14 −0.38 0.0374 ATP binding
Protein metabolism and modification
 F1RIF3 Uncharacterized protein OS = Sus scrofa GN = FAH PE = 4 SV = 1 - [F1RIF3_PIG] FAH 38.37 2 0.39 0.0010 Catabolism of the amino acid phenylalanine
 Q9GK25 Peptidyl-prolyl cis-trans isomerase (Fragment) OS = Sus scrofa PE = 2 SV = 1 - [Q9GK25_PIG] None 266.1 7 1.43 0.0025 Accelerate the folding of proteins
 I3L739 Uncharacterized protein OS = Sus scrofa GN = JMJD6 PE = 4 SV = 1 - [I3L739_PIG] JMJD6 39.99 1 −0.29 0.0193 Protein hydroxylases
 I3LK37 Uncharacterized protein (Fragment) OS = Sus scrofa PE = 3 SV = 1 - [I3LK37_PIG] GALNT7 33.39 2 −0.30 0.0248 Protein glycosylation
 F1RNR6 4-hydroxyphenylpyruvate dioxygenase OS = Sus scrofa GN = HPD PE = 3 SV = 2 - [F1RNR6_PIG] HPD 31 1 0.35 0.0391 Aromatic amino acid family metabolic process
Lipid metabolism
 I3LM15 Uncharacterized protein OS = Sus scrofa GN = AGPS PE = 4 SV = 1 - [I3LM15_PIG] AGPS 48.77 1 −0.36 0.0019 Lipid biosynthetic process
 Q9GJX2 Diazepam binding inhibitor (Fragment) OS = Sus scrofa GN = DBI PE = 2 SV = 1 - [Q9GJX2_PIG] DBI 80.13 3 0.91 0.0057 Long-chain fatty acyl-CoA binding, triglyceride metabolic process
 P27917 Apolipoprotein C-III OS = Sus scrofa GN = APOC3 PE = 1 SV = 2 - [APOC3_PIG] APOC3 226.39 7 0.78 0.0241 High-density lipoprotein particle receptor binding
Cell cytoskeleton
 P10668 Cofilin-1 OS = Sus scrofa GN = CFL1 PE = 1 SV = 3 - [COF1_PIG] CFL1 704.02 15 0.31 0.0059 Cytoskeleton organization
 Q5G6W0 Cofilin-2 (Fragment) OS = Sus scrofa PE = 2 SV = 1 - [Q5G6W0_PIG] CFL1 48.67 2 0.43 0.0073 Cytoskeleton organization
 B5APV0 Actin-related protein 2/3 complex subunit 5 OS = Sus scrofa GN = ARPC5 PE = 2 SV = 1 - [B5APV0_PIG] ARPC5 170.99 6 0.30 0.0167 Structural constituent of cytoskeleton
Miscellaneous
 Q9TSA7 Calmodulin (Fragments) OS = Sus scrofa PE = 4 SV = 1 - [Q9TSA7_PIG] None 108.72 4 1.11 0.0008 Calcium ion binding
 K7GKQ1 Uncharacterized protein OS = Sus scrofa GN = RAB9A PE = 3 SV = 1 - [K7GKQ1_PIG] RAB9A 26.6 1 −0.40 0.0071 Cytoskeletal signaling
 F1RKI3 Uncharacterized protein OS = Sus scrofa GN = HINT1 PE = 4 SV = 1 - [F1RKI3_PIG] HINT1 80.55 3 0.32 0.0073 Tumor suppressing
 I3LSY0 Uncharacterized protein OS = Sus scrofa GN = ACSM4 PE = 4 SV = 1 - [I3LSY0_PIG] ACSM4 21.13 1 0.86 0.0179 Catalytic activity
 D0G6R8 Phosphatidate cytidylyltransferase OS = Sus scrofa GN = CDS2 PE = 2 SV = 1 - [D0G6R8_PIG] CDS2 33.01 1 −0.39 0.0192 Synthesis of phosphatidylglycerol
 Q95332 Betaine--homocysteine S-methyltransferase 1 (Fragment) OS = Sus scrofa GN = BHMT PE = 1 SV = 3 - [BHMT1_PIG] BHMT 110.41 4 1.10 0.0193 Regulation of homocysteine metabolism
 F1RS34 Uncharacterized protein OS = Sus scrofa GN = GAPVD1 PE = 4 SV = 2 - [F1RS34_PIG] GAPVD1 22.69 1 −0.40 0.0207 Signal transduction
 F1ST01 Uncharacterized protein OS = Sus scrofa GN = SELENBP1 PE = 4 SV = 1 - [F1ST01_PIG] SELENBP1 936.42 22 0.33 0.0209 Selenium binding
 Q9TV62 Myosin-4 OS = Sus scrofa GN = MYH4 PE = 2 SV = 1 - [MYH4_PIG] MYH4 192.94 7 −0.83 0.0336 Motor activity
 F1RN91 Uncharacterized protein (Fragment) OS = Sus scrofa PE = 4 SV = 2 - [F1RN91_PIG] MYO18A 35.04 2 0.28 0.0355 Cell migration
 F1RPC8 Uncharacterized protein OS = Sus scrofa GN = CRYM PE = 4 SV = 2 - [F1RPC8_PIG] CRYM 59.33 2 0.49 0.0392 Thyroid hormone binding
 F2Z5W6 Uncharacterized protein OS = Sus scrofa GN = LAMTOR1 PE = 4 SV = 1 - [F2Z5W6_PIG] LAMTOR1 26.54 1 −0.37 0.0410 Guanyl-nucleotide exchange factor activity
 Q29069 Myosin light chain OS = Sus scrofa PE = 2 SV = 2 - [Q29069_PIG] None 58.61 3 −0.38 0.0458 Calcium ion binding
 O19175 Casein kinase I isoform alpha (Fragment) OS = Sus scrofa GN = CSNK1A1 PE = 2 SV = 1 - [KC1A_PIG] CSNK1A1 51.13 1 −0.44 0.0473 Protein kinase activity
 N0E654 Casein kinase II b subunit splicing isoform 476 (Fragment) OS = Sus scrofa GN = Csnk2b PE = 2 SV = 1 - [N0E654_PIG] Csnk2b 63.97 2 −0.27 0.0039 Cell proliferation and cell differentiation
  1. aUniprot_ Sus scrofa_9823 database accession number
  2. bThe name of the protein exclusive of the identifier that appears in the database
  3. cThe sum of the scores of the individual peptides
  4. dThe number of distinct peptide sequences in the protein group
  5. eDifferential protein expression in the treatment group was presented as a log2 fold change relative to the control group