Skip to main content

Table 1 Quantitative comparison of overlap human milk MFGM and bovine milk MFGM (Bold proteins are significantly different proteins by one-way ANOVA; the values are log10 average iBAQ values of proteins; Human milk samples were collected from 10 healthy mothers that were between 3 and 10 months in lactation; Bovine milk samples were collected from 30 clinically healthy cows that were between 3 weeks and 10 months in lactation; data was normally distributed)

From: An interactomics overview of the human and bovine milk proteome over lactation

Gene name Protein name HM CM Log2
(HM/CM)
P value
LTF Lactotransferrin 6.87 5.03 6.13 0.000
ALB Serum albumin 6.02 4.46 5.18 0.000
FOLR1 Folate receptor alpha 5.16 3.85 4.35 0.000
CD14 Monocyte differentiation antigen CD14 5.37 4.51 2.87 0.000
LALBA Alpha-lactalbumin 7.16 6.44 2.38 0.001
TLR2 Toll-like receptor 2 4.30 3.70 2.01 0.008
KRT79 Keratin, type II cytoskeletal 79 4.47 4.10 1.23 0.586
ATP2B2 Plasma membrane calcium-transporting ATPase 2 3.38 3.10 0.95 0.164
YWHAZ 14-3-3 protein zeta/delta 4.29 4.02 0.89 0.084
FASN Fatty acid synthase 4.02 3.81 0.70 0.125
RRAS Related RAS viral (R-ras) oncogene homolog 3.67 3.46 0.67 0.591
CSN2 Beta-casein 7.23 7.08 0.48 0.729
SPP1 Osteopontin 5.06 5.09 −0.09 0.585
RAB10 Ras-related protein Rab-10 4.55 4.61 −0.20 0.720
EEF1A1 Elongation factor 1-alpha 1 4.17 4.23 −0.22 0.686
SAR1A GTP-binding protein SAR1a 4.35 4.43 −0.26 0.737
LSS Lanosterol synthase 4.27 4.39 −0.38 0.387
STX3 Syntaxin-3 4.64 4.76 −0.39 0.300
RAB5C Ras-related protein Rab-5C 3.58 3.73 −0.51 0.850
CD9 CD9 antigen 5.79 5.99 −0.67 0.245
XDH Xanthine dehydrogenase/oxidase 6.11 6.34 −0.76 0.047
ANXA2 Annexin A2 4.20 4.43 −0.76 0.081
STOM Erythrocyte band 7 integral membrane protein 5.28 5.55 −0.88 0.027
ACTG1 Actin, cytoplasmic 2 4.71 4.98 −0.90 0.026
CD59 CD59 molecule, complement regulatory protein 6.12 6.40 −0.94 0.057
FGFBP1 Fibroblast growth factor-binding protein 1 4.60 4.90 −1.00 0.017
CIDEA Cell death activator CIDE-A 4.57 4.87 −1.02 0.077
SAR1B GTP-binding protein SAR1b 3.41 3.72 −1.03 0.280
HSP90AA1 Heat shock protein HSP 90-alpha 2.95 3.31 −1.19 0.510
RAB1A Ras-related protein Rab-1A 4.68 5.06 −1.24 0.021
EHD4 EH domain-containing protein 4 3.53 3.91 −1.26 0.077
BTN1A1 Butyrophilin subfamily 1 member A1 6.80 7.32 −1.70 0.001
PLIN2 Perilipin-2 6.24 6.80 −1.87 0.001
GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 3.79 4.36 −1.87 0.006
VAT1 Synaptic vesicle membrane protein VAT-1 homolog 3.98 4.55 −1.88 0.003
YWHAB 14-3-3 protein beta/alpha 3.03 3.60 −1.91 0.432
UBC Polyubiquitin-C 3.56 4.16 −2.02 0.001
RAB18 Ras-related protein Rab-18 5.29 5.93 −2.11 0.001
MUC1 Mucin-1 3.79 4.47 −2.26 0.046
RAC1 Ras-related C3 botulinum toxin substrate 1 3.85 4.60 −2.48 0.017
RAB2A Ras-related protein Rab-2A 3.93 4.70 −2.57 0.000
PIGR Polymeric immunoglobulin receptor 5.17 5.99 −2.73 0.000
NUCB1 Nucleobindin-1 2.58 3.54 −3.22 0.067
YKT6 Synaptobrevin homolog YKT6 3.68 4.64 −3.22 0.000
FABP3 Fatty acid-binding protein, heart 5.09 6.09 −3.33 0.001
CSN1S1 Alpha-S1-casein 6.69 7.79 −3.66 0.000
ABCG2 ATP-binding cassette, sub-family G, member 2 4.92 6.05 −3.75 0.000
ACSL1 Acyl-CoA synthetase long-chain family member 1 3.64 4.81 −3.89 0.000
HSPA8 Heat shock cognate 71 kDa protein 3.19 4.41 −4.06 0.000
DHRS1 Dehydrogenase/reductase (SDR family) member 1 3.77 5.03 −4.17 0.000
CD36 Platelet glycoprotein 4 4.78 6.25 −4.90 0.000
GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 3.40 5.34 −6.43 0.000
IGL@ IGL@ protein 4.39 6.49 −6.96 0.000
MFGE8 Lactadherin 4.46 6.72 −7.53 0.000