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Table 1 Quantitative comparison of overlap human milk MFGM and bovine milk MFGM (Bold proteins are significantly different proteins by one-way ANOVA; the values are log10 average iBAQ values of proteins; Human milk samples were collected from 10 healthy mothers that were between 3 and 10 months in lactation; Bovine milk samples were collected from 30 clinically healthy cows that were between 3 weeks and 10 months in lactation; data was normally distributed)

From: An interactomics overview of the human and bovine milk proteome over lactation

Gene name

Protein name

HM

CM

Log2

(HM/CM)

P value

LTF

Lactotransferrin

6.87

5.03

6.13

0.000

ALB

Serum albumin

6.02

4.46

5.18

0.000

FOLR1

Folate receptor alpha

5.16

3.85

4.35

0.000

CD14

Monocyte differentiation antigen CD14

5.37

4.51

2.87

0.000

LALBA

Alpha-lactalbumin

7.16

6.44

2.38

0.001

TLR2

Toll-like receptor 2

4.30

3.70

2.01

0.008

KRT79

Keratin, type II cytoskeletal 79

4.47

4.10

1.23

0.586

ATP2B2

Plasma membrane calcium-transporting ATPase 2

3.38

3.10

0.95

0.164

YWHAZ

14-3-3 protein zeta/delta

4.29

4.02

0.89

0.084

FASN

Fatty acid synthase

4.02

3.81

0.70

0.125

RRAS

Related RAS viral (R-ras) oncogene homolog

3.67

3.46

0.67

0.591

CSN2

Beta-casein

7.23

7.08

0.48

0.729

SPP1

Osteopontin

5.06

5.09

−0.09

0.585

RAB10

Ras-related protein Rab-10

4.55

4.61

−0.20

0.720

EEF1A1

Elongation factor 1-alpha 1

4.17

4.23

−0.22

0.686

SAR1A

GTP-binding protein SAR1a

4.35

4.43

−0.26

0.737

LSS

Lanosterol synthase

4.27

4.39

−0.38

0.387

STX3

Syntaxin-3

4.64

4.76

−0.39

0.300

RAB5C

Ras-related protein Rab-5C

3.58

3.73

−0.51

0.850

CD9

CD9 antigen

5.79

5.99

−0.67

0.245

XDH

Xanthine dehydrogenase/oxidase

6.11

6.34

−0.76

0.047

ANXA2

Annexin A2

4.20

4.43

−0.76

0.081

STOM

Erythrocyte band 7 integral membrane protein

5.28

5.55

−0.88

0.027

ACTG1

Actin, cytoplasmic 2

4.71

4.98

−0.90

0.026

CD59

CD59 molecule, complement regulatory protein

6.12

6.40

−0.94

0.057

FGFBP1

Fibroblast growth factor-binding protein 1

4.60

4.90

−1.00

0.017

CIDEA

Cell death activator CIDE-A

4.57

4.87

−1.02

0.077

SAR1B

GTP-binding protein SAR1b

3.41

3.72

−1.03

0.280

HSP90AA1

Heat shock protein HSP 90-alpha

2.95

3.31

−1.19

0.510

RAB1A

Ras-related protein Rab-1A

4.68

5.06

−1.24

0.021

EHD4

EH domain-containing protein 4

3.53

3.91

−1.26

0.077

BTN1A1

Butyrophilin subfamily 1 member A1

6.80

7.32

−1.70

0.001

PLIN2

Perilipin-2

6.24

6.80

−1.87

0.001

GNB1

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

3.79

4.36

−1.87

0.006

VAT1

Synaptic vesicle membrane protein VAT-1 homolog

3.98

4.55

−1.88

0.003

YWHAB

14-3-3 protein beta/alpha

3.03

3.60

−1.91

0.432

UBC

Polyubiquitin-C

3.56

4.16

−2.02

0.001

RAB18

Ras-related protein Rab-18

5.29

5.93

−2.11

0.001

MUC1

Mucin-1

3.79

4.47

−2.26

0.046

RAC1

Ras-related C3 botulinum toxin substrate 1

3.85

4.60

−2.48

0.017

RAB2A

Ras-related protein Rab-2A

3.93

4.70

−2.57

0.000

PIGR

Polymeric immunoglobulin receptor

5.17

5.99

−2.73

0.000

NUCB1

Nucleobindin-1

2.58

3.54

−3.22

0.067

YKT6

Synaptobrevin homolog YKT6

3.68

4.64

−3.22

0.000

FABP3

Fatty acid-binding protein, heart

5.09

6.09

−3.33

0.001

CSN1S1

Alpha-S1-casein

6.69

7.79

−3.66

0.000

ABCG2

ATP-binding cassette, sub-family G, member 2

4.92

6.05

−3.75

0.000

ACSL1

Acyl-CoA synthetase long-chain family member 1

3.64

4.81

−3.89

0.000

HSPA8

Heat shock cognate 71 kDa protein

3.19

4.41

−4.06

0.000

DHRS1

Dehydrogenase/reductase (SDR family) member 1

3.77

5.03

−4.17

0.000

CD36

Platelet glycoprotein 4

4.78

6.25

−4.90

0.000

GNB2

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

3.40

5.34

−6.43

0.000

IGL@

IGL@ protein

4.39

6.49

−6.96

0.000

MFGE8

Lactadherin

4.46

6.72

−7.53

0.000

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Proteome Science

ISSN: 1477-5956