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Table 2 Quantitative comparison of overlap human milk serum and bovine milk serum (Bold proteins are significantly different proteins by one-way ANOVA; the values are log10 average iBAQ values of proteins; Human milk samples were collected from 10 healthy mothers that were between 3 and 10 months in lactation; Bovine milk samples were collected from 30 clinically healthy cows that were between 3 weeks and 10 months in lactation; data was normally distributed)

From: An interactomics overview of the human and bovine milk proteome over lactation

Gene name Protein name HS CS Log2 (HS/CS) P value
ALB Serum albumin 7.30 5.27 6.75 0.000
FASN Fatty acid synthase 4.38 2.40 6.59 0.000
XDH Xanthine dehydrogenase 5.36 3.59 5.86 0.000
SERPINA3 Alpha-1-antichymotrypsin 5.44 4.02 4.72 0.000
LTF Lactoferrin 7.17 5.84 4.44 0.002
PRSS1 Alpha-trypsin chain 1 6.74 5.42 4.39 0.000
CD14 Monocyte differentiation antigen CD14 5.52 4.24 4.23 0.000
CLU Clusterin 5.74 4.64 3.66 0.002
CSN2 Beta-casein 7.80 6.79 3.34 0.002
LDHB L-lactate dehydrogenase B chain 4.25 3.30 3.16 0.124
SERPINA1 Alpha-1-antitrypsin 5.38 4.62 2.52 0.007
PIGR Polymeric immunoglobulin receptor 6.47 5.84 2.08 0.003
GC Vitamin D-binding protein 5.20 4.64 1.89 0.026
LPL Lipoprotein lipase 4.05 3.56 1.65 0.043
SPP1 osteopontin 6.35 5.95 1.34 0.107
HSPA8 Heat shock 70 kDa protein 8 3.89 3.51 1.25 0.277
LALBA Alpha-lactalbumin 7.79 7.49 1.00 0.073
SERPINF2 Alpha-2-plasmin inhibitor 3.89 3.60 0.95 0.302
FABP3 Fatty acid-binding protein 3 5.33 5.13 0.66 0.359
B2M Beta-2-microglobulin 5.47 5.36 0.37 0.779
BTN1A1 Butyrophilin subfamily 1 member A1 5.60 5.53 0.23 0.679
NUCB2 Nucleobindin 2 4.44 4.40 0.12 0.543
PLIN2 Perilipin-2 4.49 4.46 0.10 0.943
CSN1S1 Alpha-S1-casein 7.33 7.31 0.10 0.836
APOE Apolipoprotein E 3.81 3.99 −0.59 0.285
SERPINC1 Antithrombin-III 3.86 4.05 −0.64 0.677
RAB18 Ras-related protein Rab-18 3.70 3.96 −0.86 0.725
MFGE8 Lactadherin 4.88 5.16 −0.94 0.402
NPC2 Epididymal secretory protein E1 4.49 4.89 −1.32 0.513
C3 Complement C3 4.56 4.96 −1.33 0.074
AZGP1 Zinc-alpha-2-glycoprotein 4.88 5.32 −1.47 0.197
AHSG Alpha-2-HS-glycoprotein 4.32 4.83 −1.69 0.149
IGL@ IGL@ protein 6.19 6.76 −1.88 0.025
CFB Complement factor B 2.66 3.27 −2.03 0.138
ORM1 Alpha-1-acid glycoprotein 1 4.94 5.56 −2.04 0.298
FGFBP1 Fibroblast growth factor-binding protein 1 3.69 4.64 −3.16 0.002
LPO Leucine-rich alpha-2-glycoprotein 4.25 5.23 −3.26 0.004
NUCB1 Nucleobindin 1 4.05 5.35 −4.30 0.008
IDH1 Isocitrate dehydrogenase 1 3.00 4.48 −4.92 0.007