Overgrazing induces alterations in the hepatic proteome of sheep (Ovis aries): an iTRAQ-based quantitative proteomic analysis

Ren, Weibo; Hou, Xiangyang; Wang, Yuqing; Badgery, Warwick; Li, Xiliang; Ding, Yong; Guo, Huiqin; Wu, Zinian; Hu, Ningning; Kong, Lingqi; Chang, Chun; Jiang, Chao; Zhang, Jize

doi:10.1186/s12953-016-0111-z

Proteome Science

Table 3 List of differentially expressed proteins in hepatic samples from overgrazing group and light grazing group

From: Overgrazing induces alterations in the hepatic proteome of sheep (Ovis aries): an iTRAQ-based quantitative proteomic analysis

Accession^a	Description^b	Gene symbol	Fold change	p-value	Biological process GO term
Energy metabolism
W5NYL7	Uncharacterized protein OS = Ovis aries GN = MTHFD1L PE = 3 SV = 1 - [W5NYL7_SHEEP]	MTHFD1L	0.69	0.0403	ATP binding
Q5MIB6	Glycogen phosphorylase, brain form OS = Ovis aries GN = PYGB PE = 2 SV = 3 - [PYGB_SHEEP]	PYGB	0.82	0.0397	Carbohydrate metabolic process
W5PM30	Uncharacterized protein OS = Ovis aries GN = CREB3L3 PE = 4 SV = 1 - [W5PM30_SHEEP]	CREB3L3	0.72	0.0223	Maintaining systemic energy homeostasis
W5NUJ4	Uncharacterized protein OS = Ovis aries GN = NEK9 PE = 4 SV = 1 - [W5NUJ4_SHEEP]	NEK9	0.82	0.0185	ATP binding
B9VXW5	Mammalian target of rapamycin OS = Ovis aries PE = 2 SV = 1 - [B9VXW5_SHEEP]	mTOR	0.83	0.0051	ATP binding
Protein modification and metabolism
W5PJN6	Kynureninase OS = Ovis aries GN = KYNU PE = 3 SV = 1 - [W5PJN6_SHEEP]	KYNU	1.21	0.0148	Tryptophan catabolic process
W5Q678	Uncharacterized protein OS = Ovis aries GN = SEC24D PE = 4 SV = 1 - [W5Q678_SHEEP]	SEC24D	0.81	0.0369	Intracellular protein transport
W5QHW3	Uncharacterized protein OS = Ovis aries GN = THNSL2 PE = 4 SV = 1 - [W5QHW3_SHEEP]	THNSL2	0.60	0.0349	Serine binding
W5PFC9	Uncharacterized protein (Fragment) OS = Ovis aries GN = LOC101117129 PE = 4 SV = 1 - [W5PFC9_SHEEP]	LOC101117129	0.78	0.0099	Enzyme inhibitor activity
W5QF53	Uncharacterized protein OS = Ovis aries GN = ZFAND2B PE = 4 SV = 1 - [W5QF53_SHEEP]	ZFAND2B	0.67	0.0095	Maintain cellular folding capacity
W5PRG9	Histidine ammonia-lyase OS = Ovis aries GN = HAL PE = 3 SV = 1 - [W5PRG9_SHEEP]	HAL	0.83	0.0062	Elimination of ammonia from the substrate
Accession^a	Description^b	Gene symbol	Fold change	p-value	Biological process GO term
Lipid metabolism
W5PMR6	Uncharacterized protein OS = Ovis aries GN = DERL1 PE = 4 SV = 1 - [W5PMR6_SHEEP]	DERL1	0.73	0.0362	ApoB secretion
W5P8F9	Uncharacterized protein OS = Ovis aries PE = 4 SV = 1 - [W5P8F9_SHEEP]	None	0.74	0.0203	Lipid binding
W5PKK8	Uncharacterized protein OS = Ovis aries GN = ESYT1 PE = 4 SV = 1 - [W5PKK8_SHEEP]	ESYT1	0.81	0.0344	Lipid binding
W5Q6U0	Uncharacterized protein OS = Ovis aries GN = FASN PE = 4 SV = 1 - [W5Q6U0_SHEEP]	FASN	0.79	0.0147	De novo synthesis of fatty acids
Transcriptional and translational regulation
W5P328	Uncharacterized protein OS = Ovis aries GN = EIF2A PE = 4 SV = 1 - [W5P328_SHEEP]	EIF2A	1.26	0.0487	Regulation of translation
W5P2A1	Uncharacterized protein OS = Ovis aries PE = 3 SV = 1 - [W5P2A1_SHEEP]	None	0.81	0.0482	Translational elongation
W5PLU3	Uncharacterized protein OS = Ovis aries GN = ZNF207 PE = 4 SV = 1 - [W5PLU3_SHEEP]	ZNF207	0.68	0.0389	Transcription regulation and chromatin organization
W5PHI1	Uncharacterized protein (Fragment) OS = Ovis aries GN = MRPL3 PE = 3 SV = 1 - [W5PHI1_SHEEP]	MRPL3	0.59	0.0325	Structural constituent of ribosome
W5PTA9	Uncharacterized protein OS = Ovis aries GN = DCPS PE = 4 SV = 1 - [W5PTA9_SHEEP]	DCPS	0.69	0.0039	Regulation of RNA stability
B0FZM0	Ribosomal protein L14-like protein (Fragment) OS = Ovis aries PE = 2 SV = 1 - [B0FZM0_SHEEP]	None	0.75	0.0028	Structural constituent of ribosome
Accession^a	Description^b	Gene symbol	Fold change	p-value	Biological process GO term
Immune response, apoptosis and inflammation
W5QAE0	Uncharacterized protein OS = Ovis aries GN = TMBIM6 PE = 3 SV = 1 - [W5QAE0_SHEEP]	TMBIM6	1.31	0.0247	Intrinsic apoptotic signaling pathway
W5PKK4	Uncharacterized protein OS = Ovis aries GN = CCAR2 PE = 4 SV = 1 - [W5PKK4_SHEEP]	CCAR2	1.51	0.0402	Positive regulation of apoptotic process
W5PUV3	Uncharacterized protein OS = Ovis aries GN = NT5E PE = 3 SV = 1 - [W5PUV3_SHEEP]	NT5E	0.83	0.0387	Marker of lymphocyte differentiation
W5P8T5	Uncharacterized protein OS = Ovis aries GN = PPM1B PE = 3 SV = 1 - [W5P8T5_SHEEP]	PPM1B	0.73	0.0358	Protein serine/threonine phosphatase activity
W5NZ57	Proteasome subunit beta type OS = Ovis aries GN = PSMB10 PE = 3 SV = 1 - [W5NZ57_SHEEP]	PSMB10	0.78	0.0344	T cell proliferation
W5Q0Z8	Uncharacterized protein OS = Ovis aries GN = TRIM56 PE = 4 SV = 1 - [W5Q0Z8_SHEEP]	TRIM56	0.29	0.0011	Regulator of host innate immunity
Stress response and detoxification
W5PGA7	UDP-glucuronosyltransferase OS = Ovis aries GN = UGT2B7 PE = 3 SV = 1 - [W5PGA7_SHEEP]	UGT2B7	0.79	0.0376	Elimination of potentially toxic xenobiotics and endogenous compounds
W5PWA2	Uncharacterized protein OS = Ovis aries PE = 3 SV = 1 - [W5PWA2_SHEEP]	None	1.24	0.0140	Oxidoreductase activity
W5PKE4	Uncharacterized protein OS = Ovis aries PE = 4 SV = 1 - [W5PKE4_SHEEP]	None	0.56	0.0024	Oxidation reduction process
W5P214	Transgelin OS = Ovis aries GN = TAGLN PE = 3 SV = 1 - [W5P214_SHEEP]	TAGLN	0.82	0.0006	Stress response related
Cell growth and proliferation
W5Q8Q6	Uncharacterized protein OS = Ovis aries GN = KANK2 PE = 4 SV = 1 - [W5Q8Q6_SHEEP]	KANK2	0.81	0.0474	Promotion of cell proliferation
W5P0W0	Uncharacterized protein (Fragment) OS = Ovis aries GN = IST1 PE = 4 SV = 1 - [W5P0W0_SHEEP]	IST1	0.72	0.0015	Cytokinesis
Accession^a	Description^b	Gene symbol	Fold change	p-value	Biological process GO term
Cell cytoskeleton
W5PK38	Uncharacterized protein (Fragment) OS = Ovis aries GN = VASP PE = 4 SV = 1 - [W5PK38_SHEEP]	VASP	0.76	0.0135	Actin cytoskeleton organization
W5Q5K3	Uncharacterized protein (Fragment) OS = Ovis aries GN = NCKAP1 PE = 4 SV = 1 - [W5Q5K3_SHEEP]	NCKAP1	0.69	0.0022	Regulation of actin cytoskeleton
W5Q8P7	Uncharacterized protein (Fragment) OS = Ovis aries GN = SNTB1 PE = 4 SV = 1 - [W5Q8P7_SHEEP]	SNTB1	0.59	0.0004	Structural molecule activity
Miscellaneous
W5PEV3	Uncharacterized protein OS = Ovis aries GN = ARSD PE = 4 SV = 1 - [W5PEV3_SHEEP]	ARSD	1.24	0.0138	Disease marker
W5NRU6	Uncharacterized protein OS = Ovis aries GN = MYADM PE = 4 SV = 1 - [W5NRU6_SHEEP]	MYADM	1.36	0.0102	Disease marker
W5QGB6	Uncharacterized protein OS = Ovis aries GN = GCHFR PE = 4 SV = 1 - [W5QGB6_SHEEP]	GCHFR	0.79	0.0386	Negative regulation of biosynthetic process
W5P2J9	Uncharacterized protein OS = Ovis aries PE = 3 SV = 1 - [W5P2J9_SHEEP]	RUSC1	0.77	0.0342	Transferase activity
W5PMB1	Uncharacterized protein OS = Ovis aries GN = SNX3 PE = 4 SV = 1 - [W5PMB1_SHEEP]	SNX3	0.82	0.0197	Iron homeostasis

^aUniprot_Ovis aries _27110_20151123 database accession number
^bThe name of the protein exclusive of the identifier that appears in the database

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