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Table 3 List of differentially expressed proteins in hepatic samples from overgrazing group and light grazing group

From: Overgrazing induces alterations in the hepatic proteome of sheep (Ovis aries): an iTRAQ-based quantitative proteomic analysis

Accessiona Descriptionb Gene symbol Fold change p-value Biological process GO term
Energy metabolism
 W5NYL7 Uncharacterized protein OS = Ovis aries GN = MTHFD1L PE = 3 SV = 1 - [W5NYL7_SHEEP] MTHFD1L 0.69 0.0403 ATP binding
 Q5MIB6 Glycogen phosphorylase, brain form OS = Ovis aries GN = PYGB PE = 2 SV = 3 - [PYGB_SHEEP] PYGB 0.82 0.0397 Carbohydrate metabolic process
 W5PM30 Uncharacterized protein OS = Ovis aries GN = CREB3L3 PE = 4 SV = 1 - [W5PM30_SHEEP] CREB3L3 0.72 0.0223 Maintaining systemic energy homeostasis
 W5NUJ4 Uncharacterized protein OS = Ovis aries GN = NEK9 PE = 4 SV = 1 - [W5NUJ4_SHEEP] NEK9 0.82 0.0185 ATP binding
 B9VXW5 Mammalian target of rapamycin OS = Ovis aries PE = 2 SV = 1 - [B9VXW5_SHEEP] mTOR 0.83 0.0051 ATP binding
Protein modification and metabolism
 W5PJN6 Kynureninase OS = Ovis aries GN = KYNU PE = 3 SV = 1 - [W5PJN6_SHEEP] KYNU 1.21 0.0148 Tryptophan catabolic process
 W5Q678 Uncharacterized protein OS = Ovis aries GN = SEC24D PE = 4 SV = 1 - [W5Q678_SHEEP] SEC24D 0.81 0.0369 Intracellular protein transport
 W5QHW3 Uncharacterized protein OS = Ovis aries GN = THNSL2 PE = 4 SV = 1 - [W5QHW3_SHEEP] THNSL2 0.60 0.0349 Serine binding
 W5PFC9 Uncharacterized protein (Fragment) OS = Ovis aries GN = LOC101117129 PE = 4 SV = 1 - [W5PFC9_SHEEP] LOC101117129 0.78 0.0099 Enzyme inhibitor activity
 W5QF53 Uncharacterized protein OS = Ovis aries GN = ZFAND2B PE = 4 SV = 1 - [W5QF53_SHEEP] ZFAND2B 0.67 0.0095 Maintain cellular folding capacity
 W5PRG9 Histidine ammonia-lyase OS = Ovis aries GN = HAL PE = 3 SV = 1 - [W5PRG9_SHEEP] HAL 0.83 0.0062 Elimination of ammonia from the substrate
Accessiona Descriptionb Gene symbol Fold change p-value Biological process GO term
Lipid metabolism
 W5PMR6 Uncharacterized protein OS = Ovis aries GN = DERL1 PE = 4 SV = 1 - [W5PMR6_SHEEP] DERL1 0.73 0.0362 ApoB secretion
 W5P8F9 Uncharacterized protein OS = Ovis aries PE = 4 SV = 1 - [W5P8F9_SHEEP] None 0.74 0.0203 Lipid binding
 W5PKK8 Uncharacterized protein OS = Ovis aries GN = ESYT1 PE = 4 SV = 1 - [W5PKK8_SHEEP] ESYT1 0.81 0.0344 Lipid binding
 W5Q6U0 Uncharacterized protein OS = Ovis aries GN = FASN PE = 4 SV = 1 - [W5Q6U0_SHEEP] FASN 0.79 0.0147 De novo synthesis of fatty acids
Transcriptional and translational regulation
 W5P328 Uncharacterized protein OS = Ovis aries GN = EIF2A PE = 4 SV = 1 - [W5P328_SHEEP] EIF2A 1.26 0.0487 Regulation of translation
 W5P2A1 Uncharacterized protein OS = Ovis aries PE = 3 SV = 1 - [W5P2A1_SHEEP] None 0.81 0.0482 Translational elongation
 W5PLU3 Uncharacterized protein OS = Ovis aries GN = ZNF207 PE = 4 SV = 1 - [W5PLU3_SHEEP] ZNF207 0.68 0.0389 Transcription regulation and chromatin organization
 W5PHI1 Uncharacterized protein (Fragment) OS = Ovis aries GN = MRPL3 PE = 3 SV = 1 - [W5PHI1_SHEEP] MRPL3 0.59 0.0325 Structural constituent of ribosome
 W5PTA9 Uncharacterized protein OS = Ovis aries GN = DCPS PE = 4 SV = 1 - [W5PTA9_SHEEP] DCPS 0.69 0.0039 Regulation of RNA stability
 B0FZM0 Ribosomal protein L14-like protein (Fragment) OS = Ovis aries PE = 2 SV = 1 - [B0FZM0_SHEEP] None 0.75 0.0028 Structural constituent of ribosome
Accessiona Descriptionb Gene symbol Fold change p-value Biological process GO term
Immune response, apoptosis and inflammation
 W5QAE0 Uncharacterized protein OS = Ovis aries GN = TMBIM6 PE = 3 SV = 1 - [W5QAE0_SHEEP] TMBIM6 1.31 0.0247 Intrinsic apoptotic signaling pathway
 W5PKK4 Uncharacterized protein OS = Ovis aries GN = CCAR2 PE = 4 SV = 1 - [W5PKK4_SHEEP] CCAR2 1.51 0.0402 Positive regulation of apoptotic process
 W5PUV3 Uncharacterized protein OS = Ovis aries GN = NT5E PE = 3 SV = 1 - [W5PUV3_SHEEP] NT5E 0.83 0.0387 Marker of lymphocyte differentiation
 W5P8T5 Uncharacterized protein OS = Ovis aries GN = PPM1B PE = 3 SV = 1 - [W5P8T5_SHEEP] PPM1B 0.73 0.0358 Protein serine/threonine phosphatase activity
 W5NZ57 Proteasome subunit beta type OS = Ovis aries GN = PSMB10 PE = 3 SV = 1 - [W5NZ57_SHEEP] PSMB10 0.78 0.0344 T cell proliferation
 W5Q0Z8 Uncharacterized protein OS = Ovis aries GN = TRIM56 PE = 4 SV = 1 - [W5Q0Z8_SHEEP] TRIM56 0.29 0.0011 Regulator of host innate immunity
Stress response and detoxification
 W5PGA7 UDP-glucuronosyltransferase OS = Ovis aries GN = UGT2B7 PE = 3 SV = 1 - [W5PGA7_SHEEP] UGT2B7 0.79 0.0376 Elimination of potentially toxic xenobiotics and endogenous compounds
 W5PWA2 Uncharacterized protein OS = Ovis aries PE = 3 SV = 1 - [W5PWA2_SHEEP] None 1.24 0.0140 Oxidoreductase activity
 W5PKE4 Uncharacterized protein OS = Ovis aries PE = 4 SV = 1 - [W5PKE4_SHEEP] None 0.56 0.0024 Oxidation reduction process
 W5P214 Transgelin OS = Ovis aries GN = TAGLN PE = 3 SV = 1 - [W5P214_SHEEP] TAGLN 0.82 0.0006 Stress response related
Cell growth and proliferation
 W5Q8Q6 Uncharacterized protein OS = Ovis aries GN = KANK2 PE = 4 SV = 1 - [W5Q8Q6_SHEEP] KANK2 0.81 0.0474 Promotion of cell proliferation
 W5P0W0 Uncharacterized protein (Fragment) OS = Ovis aries GN = IST1 PE = 4 SV = 1 - [W5P0W0_SHEEP] IST1 0.72 0.0015 Cytokinesis
Accessiona Descriptionb Gene symbol Fold change p-value Biological process GO term
Cell cytoskeleton
 W5PK38 Uncharacterized protein (Fragment) OS = Ovis aries GN = VASP PE = 4 SV = 1 - [W5PK38_SHEEP] VASP 0.76 0.0135 Actin cytoskeleton organization
 W5Q5K3 Uncharacterized protein (Fragment) OS = Ovis aries GN = NCKAP1 PE = 4 SV = 1 - [W5Q5K3_SHEEP] NCKAP1 0.69 0.0022 Regulation of actin cytoskeleton
 W5Q8P7 Uncharacterized protein (Fragment) OS = Ovis aries GN = SNTB1 PE = 4 SV = 1 - [W5Q8P7_SHEEP] SNTB1 0.59 0.0004 Structural molecule activity
Miscellaneous
 W5PEV3 Uncharacterized protein OS = Ovis aries GN = ARSD PE = 4 SV = 1 - [W5PEV3_SHEEP] ARSD 1.24 0.0138 Disease marker
 W5NRU6 Uncharacterized protein OS = Ovis aries GN = MYADM PE = 4 SV = 1 - [W5NRU6_SHEEP] MYADM 1.36 0.0102 Disease marker
 W5QGB6 Uncharacterized protein OS = Ovis aries GN = GCHFR PE = 4 SV = 1 - [W5QGB6_SHEEP] GCHFR 0.79 0.0386 Negative regulation of biosynthetic process
 W5P2J9 Uncharacterized protein OS = Ovis aries PE = 3 SV = 1 - [W5P2J9_SHEEP] RUSC1 0.77 0.0342 Transferase activity
 W5PMB1 Uncharacterized protein OS = Ovis aries GN = SNX3 PE = 4 SV = 1 - [W5PMB1_SHEEP] SNX3 0.82 0.0197 Iron homeostasis
  1. aUniprot_Ovis aries _27110_20151123 database accession number
  2. bThe name of the protein exclusive of the identifier that appears in the database