Fig. 5From: Proteomic profiling of HBV infected liver biopsies with different fibrotic stagesProposed model for HBV related liver fibrosis. HBx interacts with HIF-1A that activates PKM expresstion and inhibits PDH expression. This causes and alternate route for Ac-CoA production that results in increased ALDH1A1 and ALDH2 expression and also ROS accumulation, leading to elevated PRDX3 levelBack to article page