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Fig. 2 | Proteome Science

Fig. 2

From: Tetrazine ligation for chemical proteomics

Fig. 2

a Three different possible tetrazine isomers. b schematic illustration of mechanism of iEDDA reaction. c frontier orbital model of neutral, normal electron demand Diels-Alder reaction and iEDDA reaction. Reprinted with permission from ref 38. Copyright 2008 American Chemical Society

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