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Scheme 1 | Proteome Science

Scheme 1

From: Tetrazine ligation for chemical proteomics

Scheme 1

Protein imaging using tetrazine ligation. Top flow : A protein of interest is genetically incorporated with bioorthogonal group embedded unnatural amino acid (UAA). Consequently, UAA is conjugated to tetrazine fluorophore (FL). Bottom flow : A small molecule probe having bioorthogonal group is incubated with proteome and binds to a protein of interest. The probe is conjugated to tetrazine FL for visualization

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