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Fig. 3 | Proteome Science

Fig. 3

From: Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes

Fig. 3

Examples of applications of thermal proteome profiling (TPP). In drug discovery, TPP can identify targets and off-targets. The latter can explain adverse effects or allow drug repurposing. TPP can also be used to explore metabolic pathways by studying post-translational modifications, protein-protein interactions or basic protein function. Further, TPP can be combined with limited proteolysis or imaging to provide further insight into protein folding dynamics. By being positioned at the border of proteomics and metabolomics, TPP can be applied to study many other biological questions

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