Table 1 The effect of DAP on the proliferation of various cell lines. The normal and cancer cells were treated with DAP up to 80 μM. The effect of DAP on cell proliferation was measured for three days with MTT assay after drug treatment. GI50 values were calculated on sigmoidal dose-response graphs after three days by GraphPad Prism
From: Daptomycin, a last-resort antibiotic, binds ribosomal protein S19 in humans
| Â | Normal cells | Cancer cells | Â | Â | Â | |
|---|---|---|---|---|---|---|
Cell lines | Chang | MCF7 | A549 | HCT116 | U87MG | Huh7 |
GI50 (μM) | >100 | 3.8 | >100 | 6.5 | >100 | >100 |