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Table 3 Assessment of affinity for C-series bivalent inhibitors for selected kinases

From: Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors

Gene Name

Dasatinib RB50 (μM)

C-0 RB50 (μM)

C-1 RB50 (μM)

C-2 RB50 (μM)

ABL1

0.014

0.115

0.029

0.019

SRC

0.008

0.075

0.045

0.038

YES1

0.009

0.153

0.070

0.041

BTK

0.119

0.272

0.399

0.246

EPHB4

0.005

0.088

0.070

0.070

LYN

0.014

0.229

0.088

0.311

  1. For affinity assessment of affinity for all kinases see Additional file 1
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ISSN: 1477-5956