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Table 3 Assessment of affinity for C-series bivalent inhibitors for selected kinases

From: Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors

Gene Name Dasatinib RB50 (μM) C-0 RB50 (μM) C-1 RB50 (μM) C-2 RB50 (μM)
ABL1 0.014 0.115 0.029 0.019
SRC 0.008 0.075 0.045 0.038
YES1 0.009 0.153 0.070 0.041
BTK 0.119 0.272 0.399 0.246
EPHB4 0.005 0.088 0.070 0.070
LYN 0.014 0.229 0.088 0.311
  1. For affinity assessment of affinity for all kinases see Additional file 1