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Fig. 5 | Proteome Science

Fig. 5

From: In vitro gentamicin exposure alters caveolae protein profile in cochlear spiral ligament pericytes

Fig. 5

Comparative visualization of the proteins uniquely segregating with caveolae in control and gentamicin treated cells. Panels a and c show the top level area polygons for control and GTM datasets respectively. Panels b and d, show the division of the top area polygons in sub-categories for the two datasets. The visualization shows a dramatic difference in the polygon sizes in GTM treated vs control cells. The “Genetic information processing” polygon shows a reduction of “Translation”, “Transcription” and “DNA maintenance” processes and an increase in the “Sorting folding and degradation processes”. All the sub-categories in the “Metabolism” polygon double the size in GTM treated cells as compared to the untreated ones and a new subcategory “Energy metabolism” appeared. The doubling in size of the “Cellular processes” in GTM treated cells, mostly accounts for by the increase of the “Vesicular transport” process and the introduction of a new subcategory “Cell growth and death”. The subcategory “Signal transduction”, accounts for the increase of the top area Environmental information processes. Control and gentamicin top area polygons panel A and C in the figure, from the top left corner clock wise are: Environmental information processes, Genetic information processes, Cellular processes, Metabolism, Organismal system, Human diseases. Control: Subcategories panel B from the top left corner clock wise are: Signaling molecule and interaction, Signal transduction, translation, DNA maintenance, Folding sorting and degradation, Transcription; Vesicular transport cellular community cytoskeleton; Other enzymes, Central carbon metabolism, Biosynthesis, Membrane transport; Digestive system, Immune system, Endocrine system; Cancer, Infectious diseases. Gentamicin: subcategories panel D, from the top left corner clock wise are: Signal transduction, Signaling molecule and interaction; Translation, DNA maintenance, Folding sorting and degradation, Transcription; Cell growth and death, Vesicular transport Cytoskeleton, Cellular community; Other enzymes, Central carbon metabolism, Biosynthesis, Membrane transport Energy metabolism; Nervous, Excretory, Circulatory, Digestive, Immune, Endocrine systems, Development; Cardiovascular, Infectious diseases Cancer, Immune and Neurodegenerative diseases

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