Skip to main content

Table 3 A, B and C. Enrichment analysis of proteins uniquely segregating with caveolae in untreated cells. The 251 proteins uniquely segregating with caveolae in untreated cells where selected as the target group for the GOrilla enrichment analysis. The control dataset plus the GTM dataset were chosen as background group. GO terms with a FDR q-value p < or = 10− 5 were considered in the table. The complete list of significantly enriched GO terms to p < 0.05 is presented as additional file [See Additional file 3]. The enrichment showed significance for terms in the categories “Biological process”, “Cellular component” and “Molecular function”. The enriched terms showed the suppressed activities and functions in the cells once GTM is administered.

From: In vitro gentamicin exposure alters caveolae protein profile in cochlear spiral ligament pericytes

A Biological process
GO term Description FDR q-value Enrichment (N, B, n, b)
GO:0090304 nucleic acid metabolic process 2.59E-10 1.96 (2597,537,249,101)
GO:0016070 RNA metabolic process 3.1E-10 2.06 (2597,455,249,90)
GO:0006139 nucleobase-containing compound metabolic process 1.86E-5 1.61 (2597,673,249,104)
GO:0046483 heterocycle metabolic process 4.34E-5 1.57 (2597,704,249,106)
GO:0006725 cellular aromatic compound metabolic process 6.41E-5 1.56 (2597,694,249,104)
GO:0006351 transcription, DNA-templated 7.04E-5 2.23 (2597,210,249,45)
GO:0097659 nucleic acid-templated transcription 6.03E-5 2.23 (2597,210,249,45)
GO:0010468 regulation of gene expression 7.14E-5 1.66 (2597,539,249,86)
GO:0032774 RNA biosynthetic process 8.61E-5 2.19 (2597,214,249,45)
GO:0006396 RNA processing 9.71E-5 2.13 (2597,230,249,47)
B Cellular component
GO term Description FDR q-value Enrichment (N, B, n, b)
GO:0044428 nuclear part 1.15E-6 1.54 (2597,855,249,126)
GO:0005634 nucleus 4.66E-6 1.38 (2597,1160,249,154)
C Molecular function
GO term Description FDR q-value Enrichment (N, B, n, b)
GO:0003676 nucleic acid binding 5.68E-10 1.70 (2597,779,249,127)
GO:0003677 DNA binding 1.58E-7 2.36 (2597,243,249,55)
GO:0000975 regulatory region DNA binding 8.02E-7 3.56 (2597,79,249,27)
GO:0044212 transcription regulatory region DNA binding 6.01E-7 3.56 (2597,79,249,27)
GO:0001067 regulatory region nucleic acid binding 9.13E-7 3.48 (2597,81,249,27)
GO:0043565 sequence-specific DNA binding 1.34E-5 3.09 (2597,91,249,27)
GO:1990837 sequence-specific double-stranded DNA binding 4.73E-5 3.48 (2597,63,249,21)