Fig. 3

Functional enrichment analyses of the significantly altered phosphoproteins. a Scatter plot showing the phosphopeptide log₂ fold-change (SRMS/control) plotted against the -Log₁₀ p-value highlighting the significantly regulated phosphopeptides (ANOVA p-value ≤0.05, upregulation fold-change cut-off = Log₂ ≥ 1.58 and downregulation fold-change cut-off = Log₂ ≤ − 1). Upregulated phosphopeptides are highlighted in orange while downregulated phosphopeptides are highlighted in blue. b IPA analyses of the top cellular and molecular processes enriched from upregulated phosphoproteins identified in the SRMS-regulated phosphoproteome (n = 60; corresponding to upregulated phosphopeptides; SRMS/Control Log₂ ≥ 1.58-fold). The activation z-score indicates the predicted upregulation (z-score > 1) or downregulation (z-score < 0) of specific cellular and molecular processes. c IPA analyses of upstream regulators for the upregulated phosphoproteins (n =  60). z-score indicates the predicted activation (z-score > 1) or inactivation (z-score < 0) of the indicated upstream proteins