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Fig. 7 | Proteome Science

Fig. 7

From: Hepatic protein Carbonylation profiles induced by lipid accumulation and oxidative stress for investigating cellular response to non-alcoholic fatty liver disease in vitro

Fig. 7

3D structure of ATP5A (PDB ID: 1NBM). Nucleotide binding region (pink), including K175 and R171 carbonylation sites, interacts with ATP (yellow) (a). Illustration of K175 amino side chain (green) interacts with ATP; nitrogen atom of the side chain (purple) and hydrogen atom (white) interact (green dash) with phosphate group of ATP (yellow) (b). Carbonylation at K175 (Red) contributes to inability of ATP binding (yellow) to nucleotide-binding region (c). The graphical representation was constructed using Discovery Studio Visualizer-Accelrys

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Proteome Science

ISSN: 1477-5956