Fig. 2

Overview of iTRAQ proteomic analysis. a Hierarchical clustering of the differentially expressed proteins. The heat map demonstrates that expression patterns were altered under hypoxia. Red denotes high relative expression, and green denotes low relative expression. b The differentially expressed proteins according to fold changes (FCs) and P values are depicted with a volcano plot. Proteins with a P < 0.05 and a FC < 5/6 or >1.2 were considered to be significantly differentially expressed. Red dots denote upregulated proteins, and green dots denote downregulated proteins