Table 3 Description of the selected exosomal proteins in cancer
From: Exploring the key communicator role of exosomes in cancer microenvironment through proteomics
Exosomal Protein | Description |
|---|---|
Breast Cancer | |
 β-actin | Breast cancer metastasis [65] |
 Tubulin-β | |
 Integrin α6/β4, α6/β1 | Lung metastasis [32] |
 Integrinαv/β5 | Liver metastasis [32] |
 BASP1 | Overexpression leads to ovarian cancer cell progression [67] |
 Enolase A | |
 PRDX1 | Induce cell growth in breast cancer and overexpressed in breast cancer [70] |
 14-3-3 protein | Bind to histone protiens and induce epigenetic changes [75] |
 Fibronectin | Tumor progression and metastasis [76] |
 Annexin A1 | Induce tumor metastasis and macrophage polarization [78,79,80] |
 5’-NTD | Overexpressed in breast cancer cells and induce metastasis [81,82,83,84,85] |
 Survivin | Overexpressed in breast cancer serum derived exoxome, Anti apoptosis [95] |
 MTA1 | Promote proliferation [96] |
 GSTP1 | Drug and chemotherapy resistance [97] |
 TGF-β1 | Drug resistance [98] |
 TPRC5 | Chemotherapy resistance [99] |
 UCH-L1 | Chemotherapy resistance [100] |
 Nephronectin | Induce tumor mestasis [101] |
 Caveolin-1 | Enriched in metastasized cancer cell [36] |
 Periostin | Enriched in metastasized cancer cell [102] |
 Myoferlin | Enriched in metastasized cancer cell [31] |
Lung Cancer | |
 Mucin 5AC, B | |
 Desmoglein-2 | overspressed in non small cell lung cancer and induce cell growth [105] |
 EGFR | |
 LRG1 | Induce angiogenesis [108] |
 Tim-3 | Induce anti-tumor immune response [110] |
 NY-SEO-1 | Overexpressed in lung cancer [111] |
 PLAP | Overexpressed in lung cancer [111] |
 EpCam | Overexpressed in lung cancer [111] |
 SGRN | Overexpressed in lung cancer [112] |
 TPM3 | Overexpressed in lung cancer [112] |
 THBS1 | Overexpressed in lung cancer [112] |
 HUWE1 | Overexpressed in lung cancer [112] |
 MUC 1 | Overexpressed in lung cancer [112] |
Colon Cancer | |
 Annexin family | |
 Tetraspanin 1 | |
Pancreatic Cancer | |
 Glypican-1 | |
 CD44 | |
 Tspan 8 | |
 EpCam | |
 MET | |
 CD104 | |
Renal Cancer | |
 MMP-9 | Abundant in renal cancer exosome [121] |
 CP | Abundant in renal cancer exosome [121] |
 PODXL | Abundant in renal cancer exosome [121] |
 DKK4 | Abundant in renal cancer exosome [121] |
 CAIX | Abundant in renal cancer exosome [121] |
 AQP1 | Abundant in renal cancer exosome [121] |
 EMMPRIN | Abundant in renal cancer exosome [121] |
 CD10 | Abundant in renal cancer exosome [121] |
 Dipeptidase 1 | Abundant in renal cancer exosome [121] |
 Syntenin-1 | Abundant in renal cancer exosome [121] |