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Table 3 Description of the selected exosomal proteins in cancer

From: Exploring the key communicator role of exosomes in cancer microenvironment through proteomics

Exosomal Protein Description
Breast Cancer
 β-actin Breast cancer metastasis [65]
 Tubulin-β Breast cancer metastasis, chemotheray resistance [66, 87]
 Integrin α6/β4, α6/β1 Lung metastasis [32]
 Integrinαv/β5 Liver metastasis [32]
 BASP1 Overexpression leads to ovarian cancer cell progression [67]
 Enolase A Breast cancer metastasis and drug resistance [68, 69]
 PRDX1 Induce cell growth in breast cancer and overexpressed in breast cancer [70]
 14-3-3 protein Bind to histone protiens and induce epigenetic changes [75]
 Fibronectin Tumor progression and metastasis [76]
 Annexin A1 Induce tumor metastasis and macrophage polarization [78,79,80]
 5’-NTD Overexpressed in breast cancer cells and induce metastasis [81,82,83,84,85]
 Survivin Overexpressed in breast cancer serum derived exoxome, Anti apoptosis [95]
 MTA1 Promote proliferation [96]
 GSTP1 Drug and chemotherapy resistance [97]
 TGF-β1 Drug resistance [98]
 TPRC5 Chemotherapy resistance [99]
 UCH-L1 Chemotherapy resistance [100]
 Nephronectin Induce tumor mestasis [101]
 Caveolin-1 Enriched in metastasized cancer cell [36]
 Periostin Enriched in metastasized cancer cell [102]
 Myoferlin Enriched in metastasized cancer cell [31]
Lung Cancer
 Mucin 5AC, B Lung cancer relapse and metastasis [103, 104]
 Desmoglein-2 overspressed in non small cell lung cancer and induce cell growth [105]
 EGFR Oncogene in lung cancer [106, 111, 113, 114]
 LRG1 Induce angiogenesis [108]
 Tim-3 Induce anti-tumor immune response [110]
 NY-SEO-1 Overexpressed in lung cancer [111]
 PLAP Overexpressed in lung cancer [111]
 EpCam Overexpressed in lung cancer [111]
 SGRN Overexpressed in lung cancer [112]
 TPM3 Overexpressed in lung cancer [112]
 THBS1 Overexpressed in lung cancer [112]
 HUWE1 Overexpressed in lung cancer [112]
 MUC 1 Overexpressed in lung cancer [112]
Colon Cancer
 Annexin family Colon cancer progression and metastasis [33, 42]
 Tetraspanin 1 Colon cancer progression and metastasis [33, 42]
Pancreatic Cancer
 Glypican-1 Abundant in pancreatic cancer exosome [31, 120]
 CD44 Abundant in pancreatic cancer exosome [31, 120]
 Tspan 8 Abundant in pancreatic cancer exosome [31, 120]
 EpCam Abundant in pancreatic cancer exosome [31, 120]
 MET Abundant in pancreatic cancer exosome [31, 120]
 CD104 Abundant in pancreatic cancer exosome [31, 120]
Renal Cancer
 MMP-9 Abundant in renal cancer exosome [121]
 CP Abundant in renal cancer exosome [121]
 PODXL Abundant in renal cancer exosome [121]
 DKK4 Abundant in renal cancer exosome [121]
 CAIX Abundant in renal cancer exosome [121]
 AQP1 Abundant in renal cancer exosome [121]
 EMMPRIN Abundant in renal cancer exosome [121]
 CD10 Abundant in renal cancer exosome [121]
 Dipeptidase 1 Abundant in renal cancer exosome [121]
 Syntenin-1 Abundant in renal cancer exosome [121]