Fig. 1
From: NEK10 interactome and depletion reveal new roles in mitochondria
NEK10 interacts with mitochondrial protein partners. Interaction network of human NEK10 with partners identified by IP-LC-MS/MS reveals mitochondrial proteins enrichment after zeocin treatment. The proteomic data retrieved from IP-LC-MS/MS was submitted to the Integrated Interactome System (IIS) platform (National Laboratory of Biosciences, Campinas, Brazil) [22]. The protein-protein interaction network (PPI) was generated using Cytoscape software [24]. a The fold change in the number of the proteins found after zeocin treatment, relative to before treatment, for the main cellular compartments enriched in the network is shown in the graph. ER = endoplasmic reticulum, b Protein network showing mitochondrial proteins found in samples without treatment (purple nodes) and with zeocin treatment (red nodes). Clusters were made according to the Selected Cellular Component. SIRT3 is a protein interactor retrieved from the databank by IIS platform [22]. c Table showing mitochondrial proteins found in untreated and zeocin treated samples