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Fig. 4 | Proteome Science

Fig. 4

From: Differences in plasma proteomes for active tuberculosis, latent tuberculosis and non-tuberculosis mycobacterial lung disease patients with and without ESAT-6/CFP10 stimulation

Fig. 4

Heatmap of plasma protein subset with quantitative changes among the four groups. For the protein level analysis of 2 h and 6 h timepoints after gefitinib treatment only duplicate samples were available, limiting the possibility to perform statistical analysis of altered protein levels. Still, a heatmap visualization of the protein level quantification at all timepoints indicates a gradual increase/decrease of protein levels with clearly visible patterns already 2 h after EGFRTKI treatment significantly. The comparison of the signal levels for the 152 analytes measured by multiple-sample test (ANOVA) revealed 68 proteins significantly different among the eight groups with a Z-Score > 1.5, p < 0.05 with Benjamini-Horchberg false-discovery rate (FDR; q) of 0.05 correction. All 68 ANOVA significant proteins (Benjamini-Hochberg FDR 0.01 correction) were plotted here. The genes names of the proteins were displayed on the y-axis. Blue color indicates down regulation, black color indicates no change and yellow color indicates up regulation

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ISSN: 1477-5956